铁死亡与光动力治疗协同作用：增强抗癌治疗。
Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment.
机构信息
Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation.
Institute of Biology and Biomedicine, National Research Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russian Federation; Cell Death Investigation and Therapy (CDIT) Laboratory, Department of Human Structure and Repair, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent, Ghent, Belgium.
出版信息
Trends Cancer. 2021 Jun;7(6):484-487. doi: 10.1016/j.trecan.2021.01.013. Epub 2021 Feb 25.
Photodynamic therapy (PDT) is widely used in cancer treatment; however, several challenges compromise its efficiency. We propose a synergistic action between PDT and ferroptotic cell death. PDT acts as a source of reactive oxygen species for the Fenton reaction, which may reinforce ferroptosis induction and increase PDT efficacy in anticancer therapy.
光动力疗法（PDT）被广泛应用于癌症治疗中；然而，一些挑战降低了它的效率。我们提出 PDT 与铁死亡细胞死亡之间的协同作用。PDT 作为芬顿反应的活性氧来源，这可能会增强铁死亡诱导，并提高癌症治疗中 PDT 的疗效。
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