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无症状儿科牙科患者的严重急性呼吸综合征冠状病毒 2 感染。

Severe acute respiratory syndrome coronavirus 2 infection in asymptomatic pediatric dental patients.

出版信息

J Am Dent Assoc. 2021 Apr;152(4):277-283. doi: 10.1016/j.adaj.2021.01.006. Epub 2021 Jan 19.

DOI:10.1016/j.adaj.2021.01.006
PMID:33641860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7816946/
Abstract

BACKGROUND

Children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are typically asymptomatic but contagious. The authors investigated the positivity rate of asymptomatic SARS-CoV-2 infection in pediatric dental patients.

METHODS

The authors reviewed consecutive charts of children younger than 18 years scheduled for elective dental procedures from April 1, 2020, through August 1, 2020. All patients were screened for signs and symptoms of SARS-CoV-2 infection. Asymptomatic patients scheduled for dental procedures underwent polymerase chain reaction (PCR) testing for SARS-CoV-2. Sociodemographic characteristics were abstracted, and positivity rates were calculated. Variables for patients who were SARS-CoV-2 positive and SARS-CoV-2 negative were compared using Fisher exact and Mann-Whitney U tests.

RESULTS

The sample size was 921. The median age was 6 years, and 50.9% were boys. The overall SARS-CoV-2 positivity rate was 2.3%. Age, insurance status, medical history, and dental diagnosis were comparable in patients who were SARS-CoV-2 positive and SARS-CoV-2 negative. Positivity rates were statistically higher for Hispanic or Latinx patients than other groups (P = .038).

CONCLUSIONS

Although the yield of testing was low, the systematic evaluation of asymptomatic pediatric dental cases via PCR resulted in the identification of SARS-CoV-2 carriers who could have been infectious. In this study, Hispanics or Latinx had a higher positivity rate than other demographic groups.

PRACTICAL IMPLICATIONS

PCR testing for SARS-CoV-2 of asymptomatic patients in pediatric dentistry adds value to the use of screening questionnaires for the identification of infected people who could be contagious.

摘要

背景

儿童感染严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)通常无症状但具有传染性。作者调查了儿童牙科患者无症状 SARS-CoV-2 感染的阳性率。

方法

作者回顾了 2020 年 4 月 1 日至 2020 年 8 月 1 日期间接受择期牙科手术的年龄小于 18 岁的儿童连续病历。所有患者均筛查 SARS-CoV-2 感染的症状和体征。计划进行牙科手术的无症状患者接受 SARS-CoV-2 的聚合酶链反应(PCR)检测。提取社会人口统计学特征,并计算阳性率。使用 Fisher 确切检验和 Mann-Whitney U 检验比较 SARS-CoV-2 阳性和 SARS-CoV-2 阴性患者的变量。

结果

样本量为 921 例。中位年龄为 6 岁,50.9%为男性。总体 SARS-CoV-2 阳性率为 2.3%。SARS-CoV-2 阳性和 SARS-CoV-2 阴性患者的年龄、保险状况、病史和牙科诊断相似。与其他群体相比,西班牙裔或拉丁裔患者的阳性率更高(P=0.038)。

结论

尽管检测的收益较低,但通过 PCR 对无症状儿科牙科病例进行系统评估可发现可能具有传染性的 SARS-CoV-2 携带者。在这项研究中,西班牙裔或拉丁裔的阳性率高于其他人群。

实用意义

对无症状的儿科牙科患者进行 SARS-CoV-2 的 PCR 检测,有助于使用筛查问卷识别可能具有传染性的感染者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e07/7816946/b42aa9bd1809/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e07/7816946/89e2ae33beca/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e07/7816946/b42aa9bd1809/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e07/7816946/89e2ae33beca/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e07/7816946/b42aa9bd1809/gr2_lrg.jpg

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