Shirazi Sajjad, Stanford Clark M, Cooper Lyndon F
Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, 801 S Paulina St, Chicago, IL 60612, USA.
Department of Restorative Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA.
J Clin Med. 2021 Mar 10;10(6):1158. doi: 10.3390/jcm10061158.
Knowledge about the detection potential and detection rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various body fluids and sites is important for dentists since they, directly or indirectly, deal with many of these fluids/sites in their daily practices. In this study, we attempt to review the latest evidence and meta-analysis studies regarding the detection rate of SARS-CoV-2 in different body specimens and sites as well as the characteristics of these sample. The presence/detection of SARS-CoV-2 viral biomolecules (nucleic acid, antigens, antibody) in different clinical specimens depends greatly on the specimen type and timing of collection. These specimens/sites include nasopharynx, oropharynx, nose, saliva, sputum, bronchoalveolar lavage, stool, urine, ocular fluid, serum, plasma and whole blood. The relative detection rate of SARS-CoV-2 viral biomolecules in each of these specimens/sites is reviewed in detail within the text. The infectious potential of these specimens depends mainly on the time of specimen collection and the presence of live replicating viral particles.
对于牙医来说，了解严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在各种体液和部位的检测潜力及检出率非常重要，因为他们在日常工作中会直接或间接地接触到许多此类体液和部位。在本研究中，我们试图回顾有关SARS-CoV-2在不同身体标本和部位的检出率以及这些样本特征的最新证据和荟萃分析研究。SARS-CoV-2病毒生物分子（核酸、抗原、抗体）在不同临床标本中的存在/检测很大程度上取决于标本类型和采集时间。这些标本/部位包括鼻咽、口咽、鼻腔、唾液、痰液、支气管肺泡灌洗、粪便、尿液、眼液、血清、血浆和全血。本文将详细综述这些标本/部位中SARS-CoV-2病毒生物分子的相对检出率。这些标本的感染潜力主要取决于标本采集时间和活的复制病毒颗粒的存在情况。
