Dong Zuoxiang, Meng Xinyue, Yang Wei, Zhang Jinfeng, Sun Peng, Zhang Huawei, Fang Xing, Wang Dong-An, Fan Changjiang
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266000, Shandong, China; Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China.
Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao 266000, Shandong, China.
Mater Sci Eng C Mater Biol Appl. 2021 Mar;122:111949. doi: 10.1016/j.msec.2021.111949. Epub 2021 Feb 6.
Gelatin has various attractive features as biomedical materials, for instance, biocompatibility, low immunogenicity, biodegradability, and ease of manipulation. In recent years, various gelatin-based microspheres (GMSs) have been fabricated with innovative technologies to serve as sustained delivery vehicles of drugs and genetic materials as well as beneficial bacteria. Moreover, GMSs have exhibited promising potentials to act as both cell carriers and 3D scaffold components in tissue engineering and regenerative medicine, which not only exhibit excellent injectability but also could be integrated into a macroscale construct with the laden cells. Herein, we aim to thoroughly summarize the recent progress in the preparations and biomedical applications of GMSs and then to point out the research direction in future. First, various methods for the fabrication of GMSs will be described. Second, the recent use of GMSs in tumor embolization and in the delivery of cells, drugs, and genetic material as well as bacteria will be presented. Finally, several key factors that may enhance the improvement of GMSs were suggested as delivery vehicles.
明胶作为生物医学材料具有多种吸引人的特性，例如生物相容性、低免疫原性、生物可降解性以及易于操作。近年来，各种基于明胶的微球（GMSs）已通过创新技术制备出来，用作药物、遗传物质以及有益细菌的缓释载体。此外，GMSs在组织工程和再生医学中作为细胞载体和三维支架组件展现出了有前景的潜力，它们不仅具有出色的可注射性，还能与负载的细胞整合到宏观构建物中。在此，我们旨在全面总结GMSs制备及生物医学应用的最新进展，然后指出未来的研究方向。首先，将描述制备GMSs的各种方法。其次，将介绍GMSs近期在肿瘤栓塞以及细胞、药物、遗传物质和细菌递送方面的应用。最后，提出了几个可能增强GMSs作为递送载体性能的关键因素。
