Lu Jin-Xin, Wang Yang, Zhang Yi-Jie, Shen Mei-Fen, Li Hai-Ying, Yu Zheng-Quan, Chen Gang
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province; Department of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui Province, China.
Neural Regen Res. 2021 Oct;16(10):1950-1957. doi: 10.4103/1673-5374.308074.
The regulation of mRNA localization and local translation play vital roles in the maintenance of cellular structure and function. Many human neurodegenerative diseases, such as fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, and spinal muscular atrophy, have been characterized by pathological changes in neuronal axons, including abnormal mRNA translation, the loss of protein expression, or abnormal axon transport. Moreover, the same protein and mRNA molecules have been associated with variable functions in different diseases due to differences in their interaction networks. In this review, we briefly examine fragile X syndrome, amyotrophic lateral sclerosis, Alzheimer's disease, and spinal muscular atrophy, with a focus on disease pathogenesis with regard to local mRNA translation and axon transport, suggesting possible treatment directions.
mRNA定位和局部翻译的调控在维持细胞结构和功能方面发挥着至关重要的作用。许多人类神经退行性疾病，如脆性X综合征、肌萎缩侧索硬化症、阿尔茨海默病和脊髓性肌萎缩症，其特征是神经元轴突发生病理变化，包括异常的mRNA翻译、蛋白质表达缺失或轴突运输异常。此外，由于相互作用网络的差异，相同的蛋白质和mRNA分子在不同疾病中具有不同的功能。在这篇综述中，我们简要研究脆性X综合征、肌萎缩侧索硬化症、阿尔茨海默病和脊髓性肌萎缩症，重点关注局部mRNA翻译和轴突运输方面的疾病发病机制，提出可能的治疗方向。
