病例报告：一名感染新冠病毒的儿童的胰岛素依赖型糖尿病和糖尿病酮症酸中毒
Case Report: Insulin-Dependent Diabetes Mellitus and Diabetic Keto-Acidosis in a Child With COVID-19.
作者信息
Nielsen-Saines Karin, Li Erica, Olivera Adriana Martinez, Martin-Blais Rachel, Bulut Yonca
机构信息
Division of Pediatric Infectious Diseases, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Division of Critical Care Medicine, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
出版信息
Front Pediatr. 2021 Feb 10;9:628810. doi: 10.3389/fped.2021.628810. eCollection 2021.
Abstract
During the COVID pandemic, a surge in pediatric Type 1 Diabetes Mellitus (T1DM) cases appears to be occurring, potentially due to the presence of autoantibody-induced immune dysregulation triggered by COVID-19. We describe one such case in a previously healthy 7-year-old with asymptomatic COVID-19 presenting with a high nasopharyngeal SARS CoV-2 virus load, detectable COVID-19 IgG antibodies, diabetic keto-acidosis and islet cell autoantibodies. COVID-19 is not a trivial disease in children and adolescents and can lead to lifelong sequelae such as T1DM. Raising awareness about a possible association between COVID-19 and T1DM in children is critical.
摘要
在新冠疫情期间，儿童1型糖尿病（T1DM）病例似乎出现激增，这可能是由于新冠病毒引发的自身抗体诱导的免疫失调所致。我们描述了这样一个病例，一名此前健康的7岁儿童感染了无症状新冠病毒，鼻咽部严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒载量高，可检测到新冠病毒IgG抗体，出现糖尿病酮症酸中毒和胰岛细胞自身抗体。新冠病毒对儿童和青少年来说并非小病，可能会导致如1型糖尿病等终身后遗症。提高对新冠病毒与儿童1型糖尿病之间可能存在关联的认识至关重要。
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