Zhang Yin-Nan, Li Hui, Shen Zhi-Wei, Xu Chang, Huang Yue-Jun, Wu Ren-Hua
Department of Rehabilitation Medicine, Mental Health Center of Shantou University, Shantou 515000, Guangdong Province, China.
Mental Health Center of Shantou University, Shantou 515000, Guangdong Province, China.
World J Clin Cases. 2021 Feb 26;9(6):1304-1317. doi: 10.12998/wjcc.v9.i6.1304.
Previous studies using voxel-based morphometry (VBM) revealed changes in gray matter volume (GMV) of patients with depression, but the differences between patients with bipolar disorder (BD) and unipolar depression (UD) are less known.
To analyze the whole-brain GMV data of patients with untreated UD and BD compared with healthy controls.
Fourteen patients with BD and 20 with UD were recruited from the Mental Health Center of Shantou University between August 2014 and July 2015, and 20 non-depressive controls were recruited. After routine three-plane positioning, axial T2WI scanning was performed. The connecting line between the anterior and posterior commissures was used as the scanning baseline. The scanning range extended from the cranial apex to the foramen magnum. Categorical data are presented as frequencies and were analyzed using the Fisher exact test.
There were no significant intergroup differences in gender, age, or years of education. Disease course, age at the first episode, and Hamilton depression rating scale scores were similar between patients with UD and those with BD. Compared with the non-depressive controls, patients with BD showed smaller GMVs in the right inferior temporal gyrus, left middle temporal gyrus, right middle occipital gyrus, and right superior parietal gyrus and larger GMVs in the midbrain, left superior frontal gyrus, and right cerebellum. In contrast, UD patients showed smaller GMVs than the controls in the right fusiform gyrus, left inferior occipital gyrus, left paracentral lobule, right superior and inferior temporal gyri, and the right posterior lobe of the cerebellum, and larger GMVs than the controls in the left posterior central gyrus and left middle frontal gyrus. There was no difference in GMV between patients with BD and UD.
Using VBM, the present study revealed that patients with UD and BD have different patterns of changes in GMV when compared with healthy controls.
以往基于体素的形态学测量（VBM）研究揭示了抑郁症患者灰质体积（GMV）的变化，但双相情感障碍（BD）患者与单相抑郁症（UD）患者之间的差异尚鲜为人知。
分析未经治疗的UD和BD患者与健康对照者的全脑GMV数据。
2014年8月至2015年7月间，从汕头大学精神卫生中心招募了14例BD患者和20例UD患者，并招募了20名非抑郁对照者。进行常规三平面定位后，行轴位T2WI扫描。以前后连合之间的连线作为扫描基线。扫描范围从颅顶延伸至枕骨大孔。分类数据以频数表示，并采用Fisher确切概率法进行分析。
三组在性别、年龄或受教育年限方面无显著组间差异。UD患者与BD患者的病程、首发年龄及汉密尔顿抑郁量表评分相似。与非抑郁对照者相比，BD患者右侧颞下回、左侧颞中回、右侧枕中回和右侧顶上小叶的GMV较小，而中脑、左侧额上回和右侧小脑的GMV较大。相比之下，UD患者右侧梭状回、左侧枕下回、左侧中央旁小叶、右侧颞上回和颞下回以及右侧小脑后叶的GMV较对照者小，而左侧中央后回和左侧额中回的GMV较对照者大。BD患者与UD患者之间的GMV无差异。
本研究采用VBM揭示，与健康对照者相比，UD和BD患者的GMV变化模式不同。
