Sahu Amit Kumar, Sreepadmanabh M, Rai Mahendra, Chande Ajit
Molecular Virology Laboratory, Indian Institute of Science Education and Research (IISER) Bhopal, Indore By-Pass Road, Bhopal, 462066 India.
Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra 444602 India.
Virusdisease. 2021 Mar;32(1):1-12. doi: 10.1007/s13337-021-00653-y. Epub 2021 Feb 22.
The COVID-19 pandemic has elicited a rapid response from the scientific community with significant advances in understanding the causative pathogen (SARS-CoV-2). Mechanisms of viral transmission and pathogenesis, as well as structural and genomic details, have been reported, which are essential in guiding containment, treatment, and vaccine development efforts. Here, we present a concise review of the recent research in these domains and an exhaustive analysis of the genomic origins of SARS-CoV-2. Particular emphasis has been placed on the pathology and disease progression of COVID-19 as documented by recent clinical studies, in addition to the characteristic immune responses involved therein. Furthermore, we explore the potential of nanomaterials and nanotechnology to develop diagnostic tools, drug delivery systems, and personal protective equipment design within the ongoing pandemic context. We present this as a ready resource for researchers to gain succinct, up-to-date insights on SARS-CoV-2.
新冠疫情引发了科学界的迅速反应，在了解致病病原体（严重急性呼吸综合征冠状病毒2，即SARS-CoV-2）方面取得了重大进展。病毒传播和发病机制以及结构和基因组细节已有报道，这些对于指导防控、治疗和疫苗研发工作至关重要。在此，我们对这些领域的最新研究进行简要综述，并对SARS-CoV-2的基因组起源进行详尽分析。除了其中涉及的特征性免疫反应外，近期临床研究记录的新冠病理和疾病进展也受到了特别关注。此外，我们探讨了在当前疫情背景下，纳米材料和纳米技术在开发诊断工具、药物递送系统及个人防护装备设计方面的潜力。我们将此作为研究人员获取关于SARS-CoV-2简洁、最新见解的现成资源呈现。
