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锆基金属有机框架材料限域的铂纳米颗粒用于葡萄糖检测，具有增强的类酶活性

Pt Nanoparticles Confined by Zirconium Metal-Organic Frameworks with Enhanced Enzyme-like Activity for Glucose Detection.

作者信息

Wang Hanhan, Zhao Jun, Liu Chuang, Tong Yuping, He Weiwei

机构信息

Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, 88 Bayi Road, Xuchang, Henan 461000, P. R. China.

School of Civil Engineering and Communication, North China University of Water Resources and Electric Power, 36 Beihuan Road, Zhengzhou, Henan 450045, China.

出版信息

ACS Omega. 2021 Feb 11;6(7):4807-4815. doi: 10.1021/acsomega.0c05747. eCollection 2021 Feb 23.

DOI:10.1021/acsomega.0c05747
PMID:33644589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7905824/
Abstract

Metal nanozymes hold promise for chemical and biological applications, and their implementation relies on high catalytic efficiency and stability. Using the metal-organic framework as an ideal carrier for well-dispersed ultra-small metal nanoparticles (NPs) is beneficial for improving the catalytic efficiency of nanozymes. In this study, a zirconium-based metal organic framework (UiO-66) with good chemical stability and high porosity was synthesized and used to construct Pt/UiO-66 nanocomposites. The percentage of Pt in UiO-66 can be tuned easily by adjusting the feeding amount of PtCl . Because of the confinement effect of mesopores, the Pt particles with an average diameter of 3.8 nm are formed and dispersed throughout the pores of the UiO-66 particle. The Pt/UiO-66 composites show efficient oxidase- and peroxidase-like activity. Both the oxidase- and peroxidase-like activities are dependent on the Pt percentage. Pt/UiO-66-6% exhibits enhanced peroxidase-like activity, ∼3.9 times higher than that of commercial Pt/C with 10 wt % Pt. We propose that the construction of Pt/UiO-66 increased the utilization efficiency and stability of Pt NPs and provided more active sites for catalytic reactions. Using the peroxidase-like activity of Pt/UiO-66, a colorimetric method that can be used for actual blood glucose detection was developed for the specific detection of glucose with a limit of detection of 0.033 mM.

摘要

金属纳米酶在化学和生物应用方面具有广阔前景，其应用依赖于高催化效率和稳定性。将金属有机框架用作分散良好的超小金属纳米颗粒（NPs）的理想载体，有利于提高纳米酶的催化效率。在本研究中，合成了具有良好化学稳定性和高孔隙率的锆基金属有机框架（UiO-66），并用于构建Pt/UiO-66纳米复合材料。通过调整PtCl的进料量，可以轻松调节UiO-66中Pt的百分比。由于中孔的限域效应，形成了平均直径为3.8 nm的Pt颗粒，并分散在整个UiO-66颗粒的孔隙中。Pt/UiO-66复合材料表现出高效的氧化酶和过氧化物酶样活性。氧化酶和过氧化物酶样活性均取决于Pt的百分比。Pt/UiO-66-6%表现出增强的过氧化物酶样活性，比含10 wt%Pt的商业Pt/C高约3.9倍。我们认为，Pt/UiO-66的构建提高了Pt NPs的利用效率和稳定性，并为催化反应提供了更多活性位点。利用Pt/UiO-66的过氧化物酶样活性，开发了一种可用于实际血糖检测的比色法，用于葡萄糖的特异性检测，检测限为0.033 mM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/97c91da5adef/ao0c05747_0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/2d3e57a6fe71/ao0c05747_0006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/890c257a9708/ao0c05747_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/97c91da5adef/ao0c05747_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/19a5109d167f/ao0c05747_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/a98fa696450d/ao0c05747_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/bc9c0c74f2bc/ao0c05747_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/75fe0229cf94/ao0c05747_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/53c4d79bb2b1/ao0c05747_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/2d3e57a6fe71/ao0c05747_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/d7ac099009d0/ao0c05747_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/890c257a9708/ao0c05747_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ac7e/7905824/97c91da5adef/ao0c05747_0009.jpg

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Nanoscale Adv. 2019 Dec 19;2(2):734-745. doi: 10.1039/c9na00508k. eCollection 2020 Feb 18.
2
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ACS Cent Sci. 2020 Aug 26;6(8):1288-1301. doi: 10.1021/acscentsci.0c00512. Epub 2020 Jul 7.
3
In Situ Fabrication of Ultrasmall Gold Nanoparticles/2D MOFs Hybrid as Nanozyme for Antibacterial Therapy.
Nanozymes based on octahedral platinum nanocrystals with {111} surface facets: glucose oxidase mimicking activity in electrochemical sensors.
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Mikrochim Acta. 2023 Sep 30;190(10):425. doi: 10.1007/s00604-023-05992-9.
4
Nanoscale designing of metal organic framework moieties as efficient tools for environmental decontamination.作为环境净化有效工具的金属有机骨架部分的纳米级设计。
Nanoscale Adv. 2023 Jun 15;5(15):3782-3802. doi: 10.1039/d3na00169e. eCollection 2023 Jul 25.
5
An origami-based colorimetric sensor for detection of hydrogen peroxide and glucose using sericin capped silver nanoparticles.基于折纸术的比色传感器，用于检测用过氧化氢和葡萄糖的丝胶蛋白封端的银纳米粒子。
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9
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Sci Rep. 2017 Jan 4;7:40103. doi: 10.1038/srep40103.