CrossTalk opposing view: Ketone bodies are not an important metabolic fuel for the heart.
作者信息
Brahma Manoja K, Wende Adam R, McCommis Kyle S
机构信息
Signal Transduction and Metabolism Laboratory, Université libre de Bruxelles, Brussels, Belgium.
Division of Molecular & Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
J Physiol. 2022 Mar;600(5):1005-1007. doi: 10.1113/JP281005. Epub 2021 Mar 11.
Abstract
摘要
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CrossTalk opposing view: Ketone bodies are not an important metabolic fuel for the heart.相互矛盾的观点：酮体并非心脏重要的代谢燃料。
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Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure.酮酯治疗改善心力衰竭临床前模型的心脏功能并减少病理性重构。
Circ Heart Fail. 2021 Jan;14(1):e007684. doi: 10.1161/CIRCHEARTFAILURE.120.007684. Epub 2020 Dec 28.
2
Myocardial ketone body utilization in patients with heart failure: The impact of oral ketone ester.心力衰竭患者心肌酮体利用：口服酮酯的影响。
Metabolism. 2021 Feb;115:154452. doi: 10.1016/j.metabol.2020.154452. Epub 2020 Nov 26.
3
Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice.线粒体丙酮酸载体缺陷型小鼠心力衰竭的营养调控。
Nat Metab. 2020 Nov;2(11):1232-1247. doi: 10.1038/s42255-020-00296-1. Epub 2020 Oct 26.
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Mitochondrial pyruvate carriers are required for myocardial stress adaptation.线粒体丙酮酸载体对于心肌应激适应是必需的。
Nat Metab. 2020 Nov;2(11):1248-1264. doi: 10.1038/s42255-020-00288-1. Epub 2020 Oct 26.
5
Comprehensive quantification of fuel use by the failing and nonfailing human heart.全面量化衰竭和非衰竭人心肌的燃料利用。
Science. 2020 Oct 16;370(6514):364-368. doi: 10.1126/science.abc8861.
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Ketone bodies: beyond their role as a potential energy substrate in exercise.酮体：超越其在运动中作为潜在能量底物的作用。
J Physiol. 2020 Nov;598(21):4749-4750. doi: 10.1113/JP280597. Epub 2020 Oct 8.
7
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization.葡萄糖供应增加可减轻心肌酮体的利用。
J Am Heart Assoc. 2020 Aug 4;9(15):e013039. doi: 10.1161/JAHA.119.013039. Epub 2020 Jul 30.
8
In vitro ketone-supported mitochondrial respiration is minimal when other substrates are readily available in cardiac and skeletal muscle.在心脏和骨骼肌中，当其他底物容易获得时，体外酮支持的线粒体呼吸是最小的。
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Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.酮体氧化增加为衰竭的心脏提供了额外的能量，而不改善心脏效率。
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