Jiang Quan, Li Yan, Song Ya-Gang, Miao Yan-Yan, Miao Ming-San
Henan University of Chinese Medicine Zhengzhou 450046,China.
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(4):772-776. doi: 10.19540/j.cnki.cjcmm.20200916.603.
The evaluation standard of LEAD animal model was established according to the understanding of the etiology and pathogenesis of diabetic lower extremity vascular disease based on Chinese and Western medicine. The consistency between the existing LEAD animal model and the clinical characteristics of traditional Chinese and Western medicine was analyzed and evaluated. The advantages and disadvantages of the existing model were compared,the application scope of different models was considered,and the possible improvement methods of the existing model were proposed,so as to provide impetus for the improvement of LEAD animal model.We should reflect more characteristics of traditional Chinese medicine syndromes in the process of model improvement and development,making the LEAD animal model to get closer to clinical features of traditional Chinese and Western medicine.
基于中西医对糖尿病下肢血管病变病因病机的认识，建立了下肢动脉硬化闭塞症（LEAD）动物模型的评价标准。分析并评价了现有的LEAD动物模型与中西医临床特征之间的一致性。比较了现有模型的优缺点，考虑了不同模型的应用范围，并提出了现有模型可能的改进方法，以期为LEAD动物模型的改进提供动力。在模型改进和发展过程中应更多地体现中医证候特点，使LEAD动物模型更接近中西医临床特征。
