Zhang Ya-Nan, Bai Ming, Hui Xiang-Xiang, Wang Sai, Miao Ming-San
College of Pharmacy,Henan University of Chinese Medicine Zhengzhou 450046,China.
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(4):767-771. doi: 10.19540/j.cnki.cjcmm.20201113.601.
Based on the characteristics of clinical symptoms of secretory otitis media in traditional Chinese and Western medicine,by reference to clinical diagnostic criteria,efforts were made to analyze and establish the Western medical diagnostic criteria and traditional Chinese medicine( TCM) syndrome differentiation criteria for secretory otitis media,and summarize the modeling methods and model characteristics of secretory otitis media animal models. According to the clinical diagnostic criteria and symptom characteristics,the coincidence degree between the existing animal models and clinical symptoms was evaluated,and its advantages and disadvantages were defined. On the basis of the statistical results,there were fewer methods for modeling secretory otitis media animal models,and only a specific relevant pathogenic mechanism could be revealed. Among them,the model with a higher coincidence degree was genetic engineering technology modeling and injection into the middle ear vesicles. The two modeling methods of bacterial factors highly coincided with the clinical symptoms of Western medicine,but both failed to reflect the TCM syndrome type. Therefore,establishing an animal model that simultaneously reflects the characteristics of clinical symptoms of secretory otitis media in traditional Chinese and Western medicine,and improving the evaluation criteria of secretory otitis media based on animal models are the main tasks of future studies on secretory otitis media.
根据分泌性中耳炎中西医临床症状特点，参照临床诊断标准，分析并制定分泌性中耳炎的西医诊断标准及中医辨证标准，总结分泌性中耳炎动物模型的造模方法及模型特点。依据临床诊断标准及症状特点，评估现有动物模型与临床症状的符合程度，明确其优缺点。统计结果显示，分泌性中耳炎动物模型的造模方法较少，且仅能揭示特定相关致病机制。其中，符合程度较高的模型是基因工程技术造模及中耳鼓室注射。细菌因素的两种造模方法与西医临床症状高度相符，但均未能体现中医证型。因此，建立同时反映分泌性中耳炎中西医临床症状特点的动物模型，完善基于动物模型的分泌性中耳炎评价标准，是未来分泌性中耳炎研究的主要任务。
