Ehrlein H J
Institute of Zoophysiology, University of Hohenheim, Stuttgart, Federal Republic of Germany.
Am J Physiol. 1988 May;254(5 Pt 1):G650-7. doi: 10.1152/ajpgi.1988.254.5.G650.
The aim of the study is to evaluate the motility of the pyloric sphincter in conscious dogs by means of extraluminal transducers. For this purpose induction coils were chronically implanted in 12 dogs. After a meal the pylorus opened and closed in relation to the gastric waves. The mean changes in pyloric diameter were 5.4 +/- 1.0 mm. During phase I of the interdigestive state, the mean degree of pyloric opening was 39 +/- 18%. Gastric contractions occurring during phase II or phase III were accompanied with a marked increase in pyloric diameter; the degree of pyloric opening was 93 +/- 12%. Duodenal instillations of hydrochloric acid or oleic acid significantly diminished the pyloric diameter. Nutrients added to a viscous meal also diminished the pyloric opening significantly in comparison with an acaloric meal. Results suggest that the pyloric sphincter is involved in the control of gastric emptying. The inductograph is a useful technique to study pyloric activity without impediment of luminal flow in animals.
本研究的目的是通过腔外换能器评估清醒犬幽门括约肌的运动性。为此，将感应线圈长期植入12只犬体内。进食后，幽门会随着胃波开合。幽门直径的平均变化为5.4±1.0毫米。在消化间期的I期，幽门平均开放程度为39±18%。在II期或III期出现的胃收缩伴随着幽门直径的显著增加；幽门开放程度为93±12%。十二指肠内注入盐酸或油酸可显著减小幽门直径。与无热量餐相比，向粘性餐中添加营养物质也会显著减小幽门开放程度。结果表明，幽门括约肌参与胃排空的控制。感应记录法是一种在不影响动物腔内血流的情况下研究幽门活动的有用技术。
