Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing 100191, China; State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering, Beihang University, Beijing 100083, China.
Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; International Joint Research Center of Aerospace Biotechnology & Medical Engineering, Beihang University, Beijing 100191, China; State Key Laboratory of Virtual Reality Technology and Systems, School of Computer Science and Engineering, Beihang University, Beijing 100083, China.
J Photochem Photobiol B. 2021 Apr;217:112156. doi: 10.1016/j.jphotobiol.2021.112156. Epub 2021 Feb 20.
Adequate sunlight exposure helps reduce bone loss and is important to bone health. Currently, about 90% of the world population spends a major portion of daily life under artificial lighting. Unlike sunlight, LED white light, the main source of artificial lighting, has no infrared radiation, which is known to be beneficial to human health. In artificial lighting environments, infrared supplementation may be used to simulate the effects of sunlight on bone metabolism. Here, we supplemented white LED exposure with infrared light in normal and ovariectomized rats for three consecutive months and examined bone turnover, bone mass, and bone density. We also analyzed the structure and function of gut microbiota in the rats. Infrared supplementation significantly reduced the abundance of Saccharibacteria and increased the abundance of Clostridiaceae 1 and Erysipelotrichaceae bacteria. Our results indicate that changes in the gut microbiome correlate well with bone mass and bone metabolism. Our work demonstrates that infrared supplementation can have a positive effect on rat bone metabolism by affecting gut microbiota. Our findings will be important considerations in the future design of healthy lighting environments that prevent or possibly ameliorate osteoporosis.
适当的阳光照射有助于减少骨质流失，对骨骼健康很重要。目前，世界上大约 90%的人口在大部分日常生活时间都处于人工照明环境下。与阳光不同，作为主要人工照明光源的 LED 白光没有红外线辐射，而红外线辐射对人类健康有益。在人工照明环境中，可能会使用红外线补充来模拟阳光对骨骼代谢的影响。在这里，我们连续三个月用红外光补充正常和去卵巢大鼠的白光照射，并检测骨转换、骨量和骨密度。我们还分析了大鼠肠道微生物群的结构和功能。红外补充显著降低了 Saccharibacteria 的丰度，增加了 Clostridiaceae 1 和 Erysipelotrichaceae 细菌的丰度。我们的结果表明，肠道微生物组的变化与骨量和骨代谢密切相关。我们的工作表明，通过影响肠道微生物群，红外补充可以对大鼠的骨骼代谢产生积极影响。我们的发现将是未来设计预防或可能改善骨质疏松症的健康照明环境的重要考虑因素。
