Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, China.
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, China.
Anal Chim Acta. 2021 Apr 1;1152:338277. doi: 10.1016/j.aca.2021.338277. Epub 2021 Feb 4.
In this work, three kinds of gold nanorods (AuNRs) with different aspect ratios were synthesized through conventional seed-mediated growth method, and the chirality of these AuNRs were characterized by circular dichroism (CD) spectroscopy. The results showed that the AuNRs with bigger aspect ratio had larger chirality. The AuNRs with different aspect ratios were applied to distinguish the enantiomers of 19 kinds of α-amino acids. It was found that AuNRs with bigger aspect ratio exhibited the stronger chiral recognition ability. As a proof-of-principle, the AuNRs with the aspect ratio of 4.8 were used to quantitatively recognize enantiomers of valine. Furthermore, the microcalorimetry was applied to study the interaction of AuNRs with amino acid enantiomers. This work provides one method to improve the chiral recognition ability of AuNRs by optimizing the aspect ratio of AuNRs, and helps people better understand the intrinsic chirality of nanostructures.
在这项工作中，通过传统的种子介导生长法合成了三种具有不同纵横比的金纳米棒（AuNRs），并通过圆二色性（CD）光谱对这些 AuNRs 的手性进行了表征。结果表明，具有较大纵横比的 AuNRs 具有更大的手性。不同纵横比的 AuNRs 被用于区分 19 种α-氨基酸的对映体。研究发现，具有较大纵横比的 AuNRs 表现出更强的手性识别能力。作为原理验证，使用纵横比为 4.8 的 AuNRs 来定量识别缬氨酸的对映体。此外，还应用微量热法研究了 AuNRs 与氨基酸对映体的相互作用。这项工作提供了一种通过优化 AuNRs 的纵横比来提高 AuNRs 手性识别能力的方法，有助于人们更好地理解纳米结构的内在手性。
