Department of Pharmacology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
University Hospital for Infectious Diseases, "Dr Fran Mihaljević," Department of Infectious Disease, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
Int Dent J. 2021 Dec;71(6):484-490. doi: 10.1016/j.identj.2021.01.004. Epub 2021 Feb 26.
The objective of this study was to analyse the pattern of medication prescribing among dental practitioners in the Republic of Croatia and to compare it with general medical practice patterns at the national level.
Data on drug prescriptions were obtained from the Croatian Health Insurance Fund. The number of dentist prescriptions, the cost of medicine denominated in the national currency (Croatian Kuna [HRK]), and the number of packages and days prescribed have been included in the analysis.
Results indicate that there was an increase in medication prescribing(+5.7%) by dentists, with antimicrobials comprising the majority, whereas national medical antimicrobial prescribing had slightly decreased. Antibiotics accounted for 80% of all dentists' prescriptions, with penicillins being the most commonly prescribed. In particular, amoxicillin with clavulanic acid accounted for 56.4% of all antibiotics prescribed. Such broad-spectrum antibiotics were prescribed more frequently than those of narrow-spectrum. Antibiotics were followed by nonsteroidal anti-inflammatory drugs, with prescribing frequency for ibuprofen increasing by 75%.
Current trends show an increase in the overall prescription rate for all medications prescribed by dentists. The largest increase was observed for the broad-spectrum amoxicillin with clavulanic acid, and ibuprofen. As the apparent widespread use of broad-spectrum antibiotics by dentists in Croatia is in contrast to national and international recommendations for antibiotic stewardship, there is a need for further prospective investigation and possible provider education and guidelines.
本研究旨在分析克罗地亚共和国牙医的药物处方模式,并将其与国家层面的一般医疗实践模式进行比较。
从克罗地亚健康保险基金获取药物处方数据。分析包括牙医处方数量、以本国货币(克罗地亚库纳(HRK)计价的药品费用)以及开方的包装数和天数。
结果表明,牙医的用药处方(增加了 5.7%)有所增加,其中以抗菌药物为主,而全国范围内的医疗抗菌药物处方略有减少。抗生素占所有牙医处方的 80%,其中青霉素类最为常用。具体而言,阿莫西林克拉维酸占所有抗生素处方的 56.4%。这种广谱抗生素的开方频率高于窄谱抗生素。抗生素之后是非甾体抗炎药,其中布洛芬的开方频率增加了 75%。
目前的趋势显示,牙医开具的所有药物的总体处方率都有所增加。广谱阿莫西林克拉维酸和布洛芬的增幅最大。由于克罗地亚牙医广泛使用广谱抗生素与国家和国际抗生素管理建议相悖,因此需要进一步进行前瞻性调查以及可能的提供者教育和指南制定。