Orak Ghazal, Chahartangi Zahra Orak, Nazeri Zahra, Ameli Fereshteh, Adelipour Maryam
Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Hyperlipidemia, School of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
BMC Res Notes. 2025 Jan 5;18(1):4. doi: 10.1186/s13104-024-07069-z.
Breast cancer is a widely prevalent and life-threatening malignancy that affects women worldwide. The identification of novel molecular markers associated with tumor progression is highly important for enhancing early detection, tailoring treatment approaches, and monitoring therapeutic outcomes. In this study, we investigated the expression patterns of four long noncoding RNAs (lncRNAs): USP30 antisense RNA1 (USP30-AS1), ELFN1 antisense RNA1 (ELFN1-AS1), GAS8 antisense RNA1 (GAS8-AS1), and small nucleolar RNA host gene 11 (SNHG11).
In breast cancer specimens, USP30-AS1 and GAS8-AS1 expression was decreased, whereas ELFN1-AS1 and SNHG11 expression was increased in breast cancer tissues compared with adjacent noncancer tissues. Decreased USP30-AS1 levels were associated with a smaller tumor size, lower tumor grade and stage, and the absence of lymphatic and vascular invasion. Lower GAS8-AS1 expression was associated with a lower tumor grade and positive estrogen and progestin receptor status. Elevated ELFN1-AS1 expression was associated with breast cancer that lacked P53 mutation. These changes suggest their promise as biomarkers for distinguishing between cancerous and noncancerous tissues.
乳腺癌是一种广泛流行且危及生命的恶性肿瘤，影响着全球女性。鉴定与肿瘤进展相关的新型分子标志物对于加强早期检测、定制治疗方案以及监测治疗效果至关重要。在本研究中，我们调查了四种长链非编码RNA（lncRNA）的表达模式：泛素特异性蛋白酶30反义RNA1（USP30-AS1）、脑源性神经营养因子家族成员1反义RNA1（ELFN1-AS1）、生长停滞特异性蛋白8反义RNA1（GAS8-AS1）和小核仁RNA宿主基因11（SNHG11）。
在乳腺癌标本中，与相邻非癌组织相比，乳腺癌组织中USP30-AS1和GAS8-AS1的表达降低，而ELFN1-AS1和SNHG11的表达增加。USP30-AS1水平降低与肿瘤较小、肿瘤分级和分期较低以及无淋巴管和血管侵犯有关。GAS8-AS1表达较低与肿瘤分级较低以及雌激素和孕激素受体状态阳性有关。ELFN1-AS1表达升高与缺乏P53突变的乳腺癌有关。这些变化表明它们有望作为区分癌组织和非癌组织的生物标志物。
