Sanchez-Cano Carlos, Alvarez-Puebla Ramon A, Abendroth John M, Beck Tobias, Blick Robert, Cao Yuan, Caruso Frank, Chakraborty Indranath, Chapman Henry N, Chen Chunying, Cohen Bruce E, Conceição Andre L C, Cormode David P, Cui Daxiang, Dawson Kenneth A, Falkenberg Gerald, Fan Chunhai, Feliu Neus, Gao Mingyuan, Gargioni Elisabetta, Glüer Claus-C, Grüner Florian, Hassan Moustapha, Hu Yong, Huang Yalan, Huber Samuel, Huse Nils, Kang Yanan, Khademhosseini Ali, Keller Thomas F, Körnig Christian, Kotov Nicholas A, Koziej Dorota, Liang Xing-Jie, Liu Beibei, Liu Sijin, Liu Yang, Liu Ziyao, Liz-Marzán Luis M, Ma Xiaowei, Machicote Andres, Maison Wolfgang, Mancuso Adrian P, Megahed Saad, Nickel Bert, Otto Ferdinand, Palencia Cristina, Pascarelli Sakura, Pearson Arwen, Peñate-Medina Oula, Qi Bing, Rädler Joachim, Richardson Joseph J, Rosenhahn Axel, Rothkamm Kai, Rübhausen Michael, Sanyal Milan K, Schaak Raymond E, Schlemmer Heinz-Peter, Schmidt Marius, Schmutzler Oliver, Schotten Theo, Schulz Florian, Sood A K, Spiers Kathryn M, Staufer Theresa, Stemer Dominik M, Stierle Andreas, Sun Xing, Tsakanova Gohar, Weiss Paul S, Weller Horst, Westermeier Fabian, Xu Ming, Yan Huijie, Zeng Yuan, Zhao Ying, Zhao Yuliang, Zhu Dingcheng, Zhu Ying, Parak Wolfgang J
Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 182, 20014 Donostia San Sebastián, Spain.
Universitat Rovira i Virgili, 43007 Tarragona, Spain.
ACS Nano. 2021 Mar 23;15(3):3754-3807. doi: 10.1021/acsnano.0c09563. Epub 2021 Mar 2.
X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploited. We highlight current and upcoming advances in this direction. We describe different X-ray-based methodologies (including those performed at synchrotron light sources and X-ray free-electron lasers) and their potentials for application to investigate the nano-bio interface. The discussion is predominantly guided by asking how such methods could better help to understand and to improve nanoparticle-based drug delivery, though the concepts also apply to nano-bio interactions in general. We discuss current limitations and how they might be overcome, particularly for future use .
基于X射线的分析方法在许多领域都有常规应用，包括物理学、化学、材料科学和工程学。然而，这些技术在生命科学和医学领域的全部潜力尚未得到充分开发。我们重点介绍了这一方向上当前和即将取得的进展。我们描述了不同的基于X射线的方法（包括在同步加速器光源和X射线自由电子激光上进行的方法）及其在研究纳米-生物界面方面的应用潜力。讨论主要围绕这些方法如何能更好地帮助理解和改进基于纳米颗粒的药物递送展开，尽管这些概念一般也适用于纳米-生物相互作用。我们讨论了当前的局限性以及如何克服这些局限性，特别是对于未来的应用。
