Vranic Sandra, Kurapati Rajendra, Kostarelos Kostas, Bianco Alberto
Nano-Cell Biology Lab, Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Centre for Nanotechnology in Medicine, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Nat Rev Chem. 2025 Mar;9(3):173-184. doi: 10.1038/s41570-024-00680-5. Epub 2025 Jan 10.
As the use of two-dimensional materials continues to grow, so too does the need to understand the environmental and biological impact of such materials. Degradation is a critical step in the life cycle of any material, but the majority of such knowledge is obtained from test tube and in vitro studies. Therefore, there remains a gap in understanding the degradability of two-dimensional materials in complex systems (in vivo) and in different ambient environments. In this Review, we highlight the need for more data-driven studies on the degradation of two-dimensional materials, including their kinetics, by-products, stability and possible downstream effects. Although challenging, building an understanding of the degradation profiles of different advanced materials in various environments at the chemical and molecular level is essential.
随着二维材料的应用不断增加，了解此类材料对环境和生物的影响的需求也在增长。降解是任何材料生命周期中的关键步骤，但此类知识大多来自试管和体外研究。因此，在理解二维材料在复杂系统（体内）和不同环境中的降解性方面仍存在差距。在本综述中，我们强调需要开展更多关于二维材料降解的数据驱动研究，包括其动力学、副产物、稳定性以及可能的下游效应。尽管具有挑战性，但在化学和分子层面了解不同先进材料在各种环境中的降解情况至关重要。
