Zhu Ping, Xu Zhihui, Cai Ling, Chen Jin
Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, China.
Suzhou Center for Disease Prevention and Control, Suzhou, 215000, Jiangsu, China.
Nanoscale Res Lett. 2021 Mar 2;16(1):41. doi: 10.1186/s11671-021-03501-6.
Porphyrin iron molecules (hemin) were successfully grafted on the channeled mesoporous silica of SBA-15 (FeIX-SBA-15), in which attached hemin molecules acted as the enzyme mimic for catalyzing oxidation reactions. In the presence of HO, the prepared FeIX-SBA-15 composite effectively degraded industrial dye Orange II and catalyzed tetramethylbenzidine hydrochloride (TMB) both in the solution and on the membrane, from which the colorimetric HO detection was achieved. Moreover, the hemin-grafted composites showed high loading content of anticancer drug of doxorubicin hydrochloride (DOX) displaying the sustained releasing behavior as monitored by real-time cell analysis, which resulted in improved inhibitory effect on cancer cells growth compared with that DOX/SBA-15. The hemin-modified mesoporous silica nanocomposite provides an integrated nanoplatform with promising biomedical applications.
卟啉铁分子（血红素）成功接枝到SBA-15的通道介孔二氧化硅上（FeIX-SBA-15），其中附着的血红素分子作为模拟酶催化氧化反应。在过氧化氢存在下，制备的FeIX-SBA-15复合材料能有效降解工业染料橙黄II，并在溶液和膜上催化盐酸四甲基联苯胺（TMB），实现了比色法检测过氧化氢。此外，血红素接枝复合材料显示出高负载量的抗癌药物盐酸阿霉素（DOX），通过实时细胞分析监测显示出缓释行为，与DOX/SBA-15相比，对癌细胞生长的抑制作用有所改善。血红素修饰的介孔二氧化硅纳米复合材料提供了一个具有广阔生物医学应用前景的集成纳米平台。
