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1
Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.参与迟发型超敏反应和抑制作用的T细胞的Ly和Ia抗原表型
J Exp Med. 1976 Jul 1;144(1):10-9. doi: 10.1084/jem.144.1.10.
2
Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.表达不同Ly成分的辅助性T细胞与抑制性T细胞的分离。II. 抗原激活：免疫后，抗原特异性抑制和辅助活性由不同的T细胞亚类介导。
J Exp Med. 1976 Jun 1;143(6):1391-40. doi: 10.1084/jem.143.6.1391.
3
Characterization of two different Ly-1+ T cell populations that mediate delayed-type hypersensitivity.介导迟发型超敏反应的两种不同Ly-1⁺ T细胞群体的特征分析。
J Immunol. 1984 Nov;133(5):2402-11.
4
T cell responses induced by the parenteral injection of antigen-modified syngeneic cells. I. Induction, characterization, and regulation of antigen-specific T helper cells involved in delayed-type hypersensitivity responses.经肠胃外注射抗原修饰的同基因细胞诱导的T细胞应答。I. 参与迟发型超敏反应的抗原特异性辅助性T细胞的诱导、特征及调节。
J Immunol. 1983 Jul;131(1):77-85.
5
Regulation of delayed-type hypersensitivity. VI. Antigen-specific suppressor T cells and suppressor factor for delayed-type hypersensitivity to histocompatibility antigens.迟发型超敏反应的调节。VI. 抗原特异性抑制性T细胞及对组织相容性抗原迟发型超敏反应的抑制因子
Transplantation. 1982 Jan;33(1):69-76.
6
The Ly phenotype of suppressor T cells arising in mice subjected to a graft-versus-host reaction.遭受移植物抗宿主反应的小鼠体内产生的抑制性T细胞的Ly表型。
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7
Effect of helper T cells on the primary in vitro production of delayed-type hypersensitivity to influenza virus.辅助性T细胞对流感病毒迟发型超敏反应体外初次产生的影响。
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8
Ly antigens: markers of T cell function on mouse spleen cells.Ly抗原：小鼠脾细胞上T细胞功能的标志物。
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9
Regulatory action of immune B cells on delayed-type hypersensitivity in mice.
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10
Augmentation of antitumor immune response by trinitrophenyl (TNP)-reactive helper T-cells: enhanced induction of tumor-specific Lyt-1+2- T-cell-mediated delayed-type hypersensitivity from spleen cells of tumor-bearing mice by TNP helpers.三硝基苯基（TNP）反应性辅助性T细胞增强抗肿瘤免疫反应：TNP辅助细胞增强荷瘤小鼠脾细胞诱导肿瘤特异性Lyt-1+2- T细胞介导的迟发型超敏反应。
J Natl Cancer Inst. 1986 Dec;77(6):1267-72.

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The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells.调节性 T 细胞在固有免疫细胞调节中的关键作用。
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Control of the inflammatory response mechanisms mediated by natural and induced regulatory T-cells in HCV-, HTLV-1-, and EBV-associated cancers.丙型肝炎病毒、人类嗜T淋巴细胞病毒1型和EB病毒相关癌症中由天然和诱导性调节性T细胞介导的炎症反应机制的调控
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Toward a Network Model of MHC Class II-Restricted Antigen Processing.迈向MHC II类限制性抗原加工的网络模型。
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Long lived protection against pneumonic tularemia is correlated with cellular immunity in peripheral, not pulmonary, organs.长期的肺鼠疫保护与外周器官（而非肺部）的细胞免疫相关。
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Special regulatory T-cell review: A rose by any other name: from suppressor T cells to Tregs, approbation to unbridled enthusiasm.特殊调节性T细胞综述：换个名字的玫瑰：从抑制性T细胞到调节性T细胞，从认可到过度热情。
Immunology. 2008 Jan;123(1):20-7. doi: 10.1111/j.1365-2567.2007.02779.x.
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7
T cell-mediated antigen presentation: a potential mechanism of infectious tolerance.T细胞介导的抗原呈递：感染性耐受的一种潜在机制。
Immunol Res. 2001;23(1):1-21. doi: 10.1385/IR:23:1:01.
8
T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.在接触性超敏反应中由半抗原致敏引发的T细胞群体，其特征在于细胞因子产生的极化模式：产生干扰素γ的（Tc1）效应性CD8 + T细胞和产生白细胞介素（Il）4/Il-10的（Th2）负调节性CD4 + T细胞。
J Exp Med. 1996 Mar 1;183(3):1001-12. doi: 10.1084/jem.183.3.1001.
9
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.白细胞介素10而非白细胞介素4是皮肤炎症反应的天然抑制剂。
J Exp Med. 1995 Jul 1;182(1):99-108. doi: 10.1084/jem.182.1.99.
10
In vitro interactions of immune lymphocytes and Cryptococcus neoformans.免疫淋巴细胞与新型隐球菌的体外相互作用。
Infect Immun. 1982 Jun;36(3):1128-38. doi: 10.1128/iai.36.3.1128-1138.1982.

本文引用的文献

1
PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES.纯化抗2,4-二硝基苯基抗体的制备
Methods Med Res. 1964;10:94-102.
2
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
3
Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
4
Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.通过环磷酰胺选择性抑制抗体形成增强T细胞介导的免疫
J Exp Med. 1974 Jun 1;139(6):1529-39. doi: 10.1084/jem.139.6.1529.
5
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
6
Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect.针对载体的细胞介导免疫与载体-半抗原辅助效应之间缺乏相关性。
J Exp Med. 1974 Mar 1;139(3):779-84. doi: 10.1084/jem.139.3.779.
7
Dissociation of T cell helper function and delayed hypersensitivity.T细胞辅助功能与迟发型超敏反应的分离
J Immunol. 1974 Dec;113(6):1872-5.
8
Ia alloantigen(s) detected on thymocytes by use of a fluorescence-activated cell sorter.通过使用荧光激活细胞分选仪在胸腺细胞上检测到Ia同种抗原。
J Immunol. 1975 Aug;115(2):584-9.
9
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.带有不同Ly抗原的T淋巴细胞功能亚类。I. 功能不同的T细胞亚类的产生是一个独立于抗原的分化过程。
J Exp Med. 1975 Jun 1;141(6):1376-89. doi: 10.1084/jem.141.6.1376.
10
Different Ly antigen phenotypes of in vitro induced helper and suppressor cells.体外诱导的辅助性细胞和抑制性细胞的不同淋巴细胞抗原表型
Nature. 1975 Dec 18;258(5536):614-6. doi: 10.1038/258614a0.

参与迟发型超敏反应和抑制作用的T细胞的Ly和Ia抗原表型

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression.

作者信息

Vadas M A, Miller J F, McKenzie I F, Chism S E, Shen F W, Boyse E A, Gamble J R, Whitelaw A M

出版信息

J Exp Med. 1976 Jul 1;144(1):10-9. doi: 10.1084/jem.144.1.10.

DOI:10.1084/jem.144.1.10
PMID:1084399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2190350/
Abstract

The Ly and Ia phenotypes of T lymphocytes involved in different functions were characterized by the use of specific antisera. T cells responsible for delayed-type hypersensitivity (DTH) and for helper functions were found to be Ly-1+,2- in contrast to cytotoxic T cells and T cells responsible for suppression of antibody responses which were Ly-1-,2+. Unlike some primed helper cells, T cells involved in DTH were Ia-. Suppressor cells in the system were Ia+.

摘要

通过使用特异性抗血清对参与不同功能的T淋巴细胞的Ly和Ia表型进行了表征。发现负责迟发型超敏反应（DTH）和辅助功能的T细胞为Ly-1 +，2-，而细胞毒性T细胞和负责抑制抗体反应的T细胞为Ly-1-，2 +。与一些致敏辅助细胞不同，参与DTH的T细胞为Ia-。该系统中的抑制细胞为Ia +。