由Ly-1+、Ly-2-和Ia-的T细胞亚群分泌Ia抗原。
Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2-, and Ia-.
作者信息
McKenzie I F, Parish C R
出版信息
J Exp Med. 1976 Sep 1;144(3):847-51. doi: 10.1084/jem.144.3.847.
Abstract
It was found that Ia antignes are rapidly secreted by a subpopulation of splenic T lymphocytes which are nonadherent and which express the surface phenotype Ly-1+, Ly-2-, and Ia-. Secretion of the Ia antigens was a metabolically active process which was inhibited by sodium azide and by Pactamycin, an inhibitor of protein synthesis.
摘要
研究发现，Ia抗原由脾脏T淋巴细胞的一个亚群快速分泌，该亚群细胞不黏附，表面表型为Ly-1+、Ly-2-和Ia-。Ia抗原的分泌是一个代谢活跃的过程，可被叠氮化钠和蛋白质合成抑制剂放线菌酮所抑制。
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本文引用的文献
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Biochemistry. 1969 Apr;8(4):1327-35. doi: 10.1021/bi00832a005.
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List of congenic lines of mice. I. Lines with differences at alloantigen loci.小鼠同类系列表。I. 在同种异体抗原位点存在差异的品系。
Transplantation. 1973 Jan;15(1):137-53. doi: 10.1097/00007890-197301000-00021.
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Variation in accessible cell surface immunoglobulin among antibody-firming cells.抗体形成细胞间可及细胞表面免疫球蛋白的变异。
J Exp Med. 1972 Jun 1;135(6):1416-22. doi: 10.1084/jem.135.6.1416.
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An ultrastructural study of lymphocytes with surface-bound immunoglobulin.一项关于带有表面结合免疫球蛋白的淋巴细胞的超微结构研究。
J Exp Med. 1972 Feb 1;135(2):267-76. doi: 10.1084/jem.135.2.267.
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The lymphocyte surface. II. Separation of Fc receptor, C'3 receptor and surface immunoglobulin-bearing lymphocytes.淋巴细胞表面。II. Fc受体、C'3受体及携带表面免疫球蛋白的淋巴细胞的分离。
Proc R Soc Lond B Biol Sci. 1974 Aug 27;187(1086):65-81. doi: 10.1098/rspb.1974.0061.
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10
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