School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China.
Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Institute of Environmental Research at Greater Bay, Ministry of Education, Guangzhou University, Guangzhou 510006, China.
Int J Mol Sci. 2021 Feb 26;22(5):2328. doi: 10.3390/ijms22052328.
In biomedical, toxicological, and optoelectronic applications, the size of nanoparticles is one of the decisive factors. Therefore, synthesis of nanoparticles with controlled sizes is required. The current methods for synthesis of larger gold nanoparticles (GNPs, ~200 nm) are complex and tedious, producing nanoparticles with a lower yield and more irregular shapes. Using ferrocene as a primary reducing agent and stabilizer, sodium citrate as a dispersant, and sodium borohydride as an accessory reducing agent, GNPs of 200 nm were synthesized in a one pot reaction. Besides the roles of reducing agent and GNP stabilizer, ferrocene also served a role of quantitative marker for ligand loading, allowing an accurate determinate of surface ligands.
在生物医学、毒理学和光电子学应用中，纳米颗粒的大小是决定因素之一。因此，需要合成具有可控尺寸的纳米颗粒。目前合成较大金纳米颗粒（GNPs，约 200nm）的方法较为复杂繁琐，得到的纳米颗粒产率较低且形状不规则。本文使用二茂铁作为主要还原剂和稳定剂，柠檬酸钠作为分散剂，硼氢化钠作为辅助还原剂，通过一锅法合成了 200nm 的 GNPs。除了作为还原剂和 GNPs 稳定剂的作用外，二茂铁还可以作为配体负载的定量标记物，从而可以准确确定表面配体。
