Cosma Stefano, Carosso Andrea Roberto, Borella Fulvio, Cusato Jessica, Bovetti Marialuisa, Bevilacqua Federica, Carosso Marco, Gervasoni Fiammetta, Sciarrone Andrea, Marozio Luca, Revelli Alberto, Rolfo Alessandro, Filippini Claudia, Ghisetti Valeria, Di Perri Giovanni, Benedetto Chiara
Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, 10126 Turin, Italy.
Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Diagnostics (Basel). 2021 Feb 26;11(3):398. doi: 10.3390/diagnostics11030398.
This prospective observational study aimed to evaluate whether women with SARS-CoV-2 infection during the first trimester of pregnancy are at higher risk of noninvasive prenatal screening test alterations and/or of congenital fetal anomalies at the second-trimester fetal anatomy scan. Maternal symptoms were secondly investigated. The study was carried out on 12-week pregnant women admitted for noninvasive prenatal testing (16 April and 22 June 2020). The cohort had seromolecular tests for SARS-CoV-2, after which they were divided into a positive case group and a negative control group. Both groups had 20-week ultrasound screening. Seventeen out of the 164 women tested positive for SARS-CoV-2 (10.3%). There were no significant differences in mean nuchal translucency thickness or biochemical markers (pregnancy-associated plasma protein A, alpha-fetoprotein, human chorionic gonadotropin, unconjugated estriol) between cases and controls ( = 0.77, 0.63, 0.30, 0.40, 0.28) or in the fetal incidence of structural anomalies at the second-trimester fetal anatomy scan ( = 0.21). No pneumonia or hospital admission due to COVID-19-related symptoms were observed. Asymptomatic or mildly symptomatic SARS-CoV-2 infection during the first trimester of pregnancy did not predispose affected women to more fetal anomalies than unaffected women. COVID-19 had a favorable maternal course at the beginning of pregnancy in our healthy cohort.
这项前瞻性观察性研究旨在评估妊娠早期感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的女性在孕中期进行无创产前筛查试验改变和/或胎儿解剖结构扫描时出现先天性胎儿异常的风险是否更高。其次对母亲的症状进行了调查。该研究针对因无创产前检测入院的怀孕12周女性开展（2020年4月16日至6月22日）。该队列进行了SARS-CoV-2的血清分子检测，之后被分为阳性病例组和阴性对照组。两组均进行了孕20周超声筛查。164名女性中有17名SARS-CoV-2检测呈阳性（10.3%）。病例组和对照组之间在平均颈项透明层厚度或生化标志物（妊娠相关血浆蛋白A、甲胎蛋白、人绒毛膜促性腺激素、未结合雌三醇）方面无显著差异（P分别为0.77、0.63、0.30、0.40、0.28），在孕中期胎儿解剖结构扫描时结构异常的胎儿发生率方面也无显著差异（P = 0.21）。未观察到因新型冠状病毒肺炎（COVID-19）相关症状导致的肺炎或住院情况。妊娠早期无症状或症状轻微的SARS-CoV-2感染不会使受影响的女性比未受影响的女性更容易出现更多胎儿异常。在我们的健康队列中，COVID-19在妊娠初期对母亲的病程影响良好。
