Kamli Majid Rasool, Alzahrani Nada A Y, Hajrah Nahid H, Sabir Jamal S M, Malik Adeel
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Center of excellence in Bionanoscience Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Microorganisms. 2021 Feb 26;9(3):499. doi: 10.3390/microorganisms9030499.
Bacteria belonging to the genus within the family Paenibacillaceae are Gram-positive, endospore-forming, and rod-shaped bacteria inhabiting diverse environments. Currently, there are eight validly described species of ; however, several unclassified species have also been reported. spp. have shown the potential for producing secondary metabolites (SMs) and demonstrated diverse types of enzyme activities. These features make them promising candidates with industrial implications. At present, genomes of 9 unique species from the genus are available, which can be utilized to decipher invaluable information on their biosynthetic potential as well as enzyme activities. In this work, we performed the comparative genome analyses of nine species representing the first such comprehensive study of this genus at the genome level. We focused on discovering the biosynthetic, biodegradation, and heavy metal resistance potential of this under-investigated genus. The results indicate that the genomes of contain SM-producing regions with diverse bioactivities, including antimicrobial and antiviral activities. Several carbohydrate-active enzymes (CAZymes) and genes involved in heavy metal resistance were also identified. Additionally, a broad range of enzyme classes were also identified in the pan-genomes, making this group of bacteria potential candidates for future investigations with industrial applications.
芽孢杆菌科内该属的细菌为革兰氏阳性、产芽孢的杆状细菌，栖息于多种环境中。目前，该属有8个已有效描述的物种；然而，也有几个未分类的物种被报道。该属的物种已显示出产生次级代谢产物（SMs）的潜力，并表现出多种类型的酶活性。这些特性使它们成为具有工业应用前景的候选对象。目前，该属9个独特物种的基因组已可得，可用于解读有关其生物合成潜力和酶活性的宝贵信息。在这项工作中，我们对9个该属物种进行了比较基因组分析，这是该属在基因组水平上的首次此类全面研究。我们专注于发现这个研究不足的属的生物合成、生物降解和重金属抗性潜力。结果表明，该属的基因组包含具有多种生物活性的次级代谢产物产生区域，包括抗菌和抗病毒活性。还鉴定了几种碳水化合物活性酶（CAZymes）和参与重金属抗性的基因。此外，在该属的泛基因组中还鉴定出了广泛的酶类，这使得这组细菌成为未来工业应用研究的潜在候选对象。
