Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China.
Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Virol J. 2021 Mar 2;18(1):49. doi: 10.1186/s12985-021-01520-4.
Membrane-associated RING-CH (MARCH) ubiquitin ligases belong to a RING finger domain E3 ligases family. Recent studies have demonstrated that MARCH proteins play critical roles during various viral infections. MARCH proteins can directly antagonize different steps of the viral life cycle and promote individual viral infection. This mini-review will focus on the latest advances of MARCH family proteins' emerging roles during viral infections.
膜相关环指（MARCH）泛素连接酶属于 RING 指结构域 E3 连接酶家族。最近的研究表明，MARCH 蛋白在各种病毒感染中发挥着关键作用。MARCH 蛋白可以直接拮抗病毒生命周期的不同步骤，并促进个体病毒感染。这篇小型综述将重点介绍 MARCH 家族蛋白在病毒感染过程中作用的最新进展。
