Calin A, Elswood J
Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, UK.
Br J Rheumatol. 1988 Apr;27(2):91-3. doi: 10.1093/rheumatology/27.2.91.
One hundred and thirty-five patients with juvenile-onset ankylosing spondylitis (JAS: less than 16 years at onset, mean 12.8 years) were compared to 135 adult-onset spondylitics (AAS: greater than 21 years at onset, mean 26.1 years), controlled for disease duration (24.5 and 23.5 years, respectively), to assess the outcome of juvenile-onset disease. Review was by postal questionnaire and health-assessment measures. The sex distribution was similar: 73% and 74% males, respectively. All parameters showed comparable outcome with the exception of the numbers in full-time employment (JAS 74%, AAS 56%; p less than 0.01) and total hip replacements (JAS 17%, AAS 4%; p less than 0.01).
(a) the premature hip is particularly at risk in ankylosing spondylitis; (b) there are few differences between the outcome of JAS and AAS; (c) overall, JAS patients do well in adulthood.
将135例青少年起病的强直性脊柱炎患者（JAS：发病年龄小于16岁，平均12.8岁）与135例成人起病的脊柱炎患者（AAS：发病年龄大于21岁，平均26.1岁）进行比较，两组疾病病程分别为24.5年和23.5年，以评估青少年起病疾病的转归。通过邮寄问卷和健康评估措施进行复查。性别分布相似：男性分别占73%和74%。除全职工作人数（JAS为74%，AAS为56%；p<0.01）和全髋关节置换术人数（JAS为17%，AAS为4%；p<0.01）外，所有参数显示出相似的转归。
（a）强直性脊柱炎患者中，不成熟的髋关节尤其危险；（b）青少年起病的强直性脊柱炎（JAS）和成人起病的强直性脊柱炎（AAS）转归差异不大；（c）总体而言，JAS患者成年后情况良好。
