来自真菌PSU-MF16的抗菌和抗真菌聚酮化合物。
Antibacterial and Antifungal Polyketides from the Fungus PSU-MF16.
作者信息
Saetang Praphatsorn, Rukachaisirikul Vatcharin, Phongpaichit Souwalak, Preedanon Sita, Sakayaroj Jariya, Hadsadee Sarinya, Jungsuttiwong Siriporn
机构信息
Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Division of Biological Science, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
出版信息
J Nat Prod. 2021 May 28;84(5):1498-1506. doi: 10.1021/acs.jnatprod.0c01308. Epub 2021 Apr 16.
Seven new polyketides including a phenol (), two diphenyl ethers ( and ), two depsidones ( and ), and two phthalides ( and ) were isolated from the fungus PSU-MF16 along with 27 known compounds. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of and - were established using comparative analyses of calculated and experimental ECD spectra. Among the new metabolites, exhibited the best antimicrobial activity against , methicillin-resistant , and with equal MIC values of 16 μg/mL. In addition, known emeguisin A displayed potent antimicrobial activity against , methicillin-resistant , and with equal MIC values of 0.5 μg/mL, compared with the standard drugs, vancomycin and amphotericin B. The structure-activity relationship study of the isolated compounds for antimicrobial activity is discussed.
从真菌PSU - MF16中分离出七种新的聚酮化合物，包括一种苯酚（）、两种二苯醚（和）、两种缩酚酸酮（和）以及两种苯酞（和），同时还分离出27种已知化合物。通过广泛的光谱分析确定了它们的结构。和 - 的绝对构型通过计算和实验ECD光谱的比较分析得以确定。在这些新代谢产物中，对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和白色念珠菌表现出最佳抗菌活性，其MIC值均为16 μg/mL。此外，已知的埃默吉辛A对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和白色念珠菌显示出强效抗菌活性，其MIC值均为0.5 μg/mL，与标准药物万古霉素和两性霉素B相比。讨论了分离出的化合物的抗菌活性构效关系研究。
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