Center for Stem Cell and Regenerative Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, Hangzhou 311121, China; Zhejiang Provincial Key Lab for Tissue Engineering and Regenerative Medicine, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Hangzhou 310058, China.
Center for Stem Cell and Regenerative Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Cell Rep. 2021 Mar 2;34(9):108803. doi: 10.1016/j.celrep.2021.108803.
Cell types are the basic building units of multicellular life, with extensive diversities. The evolution of cell types is a crucial layer of comparative cell biology but is thus far not comprehensively studied. We define a compendium of cell atlases using single-cell RNA-seq (scRNA-seq) data from seven animal species and construct a cross-species cell-type evolutionary hierarchy. We present a roadmap for the origin and diversity of major cell categories and find that muscle and neuron cells are conserved cell types. Furthermore, we identify a cross-species transcription factor (TF) repertoire that specifies major cell categories. Overall, our study reveals conservation and divergence of cell types during animal evolution, which will further expand the landscape of comparative genomics.
细胞类型是多细胞生命的基本组成单位，具有广泛的多样性。细胞类型的进化是比较细胞生物学的关键层次，但迄今为止尚未得到全面研究。我们使用来自七个动物物种的单细胞 RNA 测序 (scRNA-seq) 数据定义了细胞图谱汇编，并构建了跨物种细胞类型进化层次结构。我们提出了主要细胞类别的起源和多样性的路线图，发现肌肉和神经元细胞是保守的细胞类型。此外，我们确定了跨物种转录因子 (TF) 库，该库指定了主要的细胞类别。总体而言，我们的研究揭示了动物进化过程中细胞类型的保守性和差异性，这将进一步扩展比较基因组学的领域。
