Borsky Pavel, Chmelarova Marcela, Fiala Zdenek, Hamakova Kvetoslava, Palicka Vladimir, Krejsek Jan, Andrys Ctirad, Kremlacek Jan, Rehacek Vit, Beranek Martin, Malkova Andrea, Svadlakova Tereza, Holmannova Drahomira, Borska Lenka
Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Simkova 870, 50038, Hradec Kralove, Czech Republic.
Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Immun Ageing. 2021 Mar 3;18(1):10. doi: 10.1186/s12979-021-00220-5.
Psoriasis vulgaris is a skin autoimmune disease. Psoriatic patients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriatic patients experience accelerated aging. As accelerated aging might be the reason for the higher prevalence of comorbidities at lower chronological ages, we also wanted to investigate the relationship between aging and selected parameters of frequent psoriatic comorbidities - endocan, vascular endothelial growth factor and interleukin-17. Samples were obtained from 28 patients and 42 healthy controls. Epigenetic age measurement was based on the Horvath clock. The levels of endocan, vascular endothelial growth factor and interleukin-17 were analyzed using standardized ELISA methods.
The difference between the epigenetic age and the chronological age of each individual subject did not increase with the increasing chronological age of patients. We cannot conclude that psoriasis causes accelerated aging. However, the epigenetic and chronological age difference was significantly higher in female patients than in female controls, and the difference was correlated with endocan (r = 0.867, p = 0.0012) and vascular endothelial growth factor (r = 0.633, p = 0.0365) only in female patients.
The findings suggest a possible presence of pathophysiological processes that occur only in female psoriatic patients. These processes make psoriatic females biologically older and might lead to an increased risk of comorbidity occurrence. This study also supports the idea that autoimmune diseases cause accelerated aging, which should be further explored in the future.
寻常型银屑病是一种皮肤自身免疫性疾病。银屑病患者的预期寿命显著降低，并患有多种合并症。本研究的主要目的是确定银屑病患者是否经历加速衰老。由于加速衰老可能是导致较低实际年龄时合并症患病率较高的原因，我们还想研究衰老与银屑病常见合并症的选定参数——内脂素、血管内皮生长因子和白细胞介素-17之间的关系。样本取自28例患者和42例健康对照。表观遗传年龄测量基于霍瓦斯时钟。使用标准化酶联免疫吸附测定方法分析内脂素、血管内皮生长因子和白细胞介素-17的水平。
每个个体的表观遗传年龄与实际年龄之间的差异并未随着患者实际年龄的增加而增大。我们不能得出银屑病会导致加速衰老的结论。然而，女性患者的表观遗传年龄与实际年龄的差异显著高于女性对照组，且仅在女性患者中，该差异与内脂素（r = 0.867，p = 0.0012）和血管内皮生长因子（r = 0.633，p = 0.0365）相关。
研究结果表明可能存在仅在女性银屑病患者中发生的病理生理过程。这些过程使银屑病女性在生物学上更衰老，并可能导致合并症发生风险增加。本研究还支持自身免疫性疾病会导致加速衰老这一观点，未来应进一步探索。
