Mental Health Centre Copenhagen, Copenhagen, Denmark.
Department of Ophthalmology, Rigshospitalet-Glostrup Hospital, Copenhagen, Denmark.
Acta Neuropsychiatr. 2021 Aug;33(4):191-199. doi: 10.1017/neu.2021.6. Epub 2021 Mar 4.
Seasonal and non-seasonal depression are prevalent conditions in visual impairment (VI). We assessed the effects and side effects of light therapy in persons with severe VI/blindness who experienced recurrent depressive symptoms in winter corresponding to seasonal affective disorder (SAD) or subsyndromal SAD (sSAD).
We included 18 persons (11 with severe VI, 3 with light perception and 4 with no light perception) who met screening criteria for sSAD/SAD in a single-arm, assessor-blinded trial of 6 weeks light therapy. In the 12 persons who completed the 6 weeks of treatment, the post-treatment depression score was reduced (p < 0.001), and subjective wellbeing (p = 0.01) and sleep quality were improved (p = 0.03). In 6/12 participants (50%), the post-treatment depression score was below the cut-off set for remission. In four participants with VI, side effects (glare or transiently altered visual function) led to dropout or exclusion.
Light therapy was associated with a reduction in depressive symptoms in persons with severe VI/blindness. Eye safety remains a concern in persons with residual sight.
季节性和非季节性抑郁症在视力障碍（VI）中很常见。我们评估了光疗对患有严重 VI/失明且在冬季经历复发性抑郁症状（对应季节性情感障碍（SAD）或亚综合征 SAD（sSAD））的人对的影响和副作用。
我们在一项为期 6 周的光疗单臂、评估者盲法试验中纳入了 18 名符合 sSAD/SAD 筛查标准的人（11 名严重 VI，3 名光感，4 名无光感）。在完成 6 周治疗的 12 名患者中，治疗后抑郁评分降低（p<0.001），主观幸福感（p=0.01）和睡眠质量得到改善（p=0.03）。在 6/12 名患者（50%）中，治疗后抑郁评分低于设定的缓解标准。在 4 名 VI 患者中，副作用（眩光或短暂改变视觉功能）导致退出或排除。
光疗与严重 VI/失明患者抑郁症状的减少有关。在有残余视力的患者中，眼部安全性仍然是一个问题。
