Keypoint - Consultoria Científica, Lda, Lisbon, Portugal; Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal.
Keypoint - Consultoria Científica, Lda, Lisbon, Portugal; Nova IMS - Universidade Nova de Lisboa, Lisbon, Portugal.
Ann Epidemiol. 2021 May;57:14-21. doi: 10.1016/j.annepidem.2021.02.012. Epub 2021 Mar 2.
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. Although general and local public health report deathly cases, case fatality rates are still largely unknown. Thus, we sought to evaluate the mortality of COVID-19.
We searched PubMed and EMBASE databases for articles evaluating the clinical characteristics of COVID-19 patients that included clinical outcomes, between December 2020 and 24 April 2020. Two authors performed an independent selection using predefined terms of search.
We retrieved 33 studies with a total of 13,398 patients with COVID-19 diagnosis. The mortality rate of the COVID-19 patients was 17.1% (95% CI 12.7; 22.7, I = 96.9%). For general patients admitted to the hospital (excluding critical care-only studies) the mortality rate of the COVID-19 was 11.5% (95% CI 7.7; 16.9, I = 96.7%). Among critical illness studies (n = 7) we found a 40.5% mortality (95% CI 31.2; 50.6, I = 91.8%).
High COVID-19 mortality among general admitted patients and critical care cases should guide resources allocations and economic burden calculations during the pandemics.
冠状病毒病（COVID-19）是一种由新型冠状病毒引起的传染病。尽管一般和地方公共卫生报告了致命病例，但病死率仍知之甚少。因此，我们试图评估 COVID-19 的死亡率。
我们检索了 PubMed 和 EMBASE 数据库，以评估包含 COVID-19 患者临床结局的临床特征的文章，这些文章的纳入时间为 2020 年 12 月至 2020 年 4 月 24 日。两名作者使用预定义的搜索词进行了独立选择。
我们检索到 33 项研究，共纳入了 13398 例 COVID-19 患者。COVID-19 患者的死亡率为 17.1%（95%CI 12.7%至 22.7%，I²=96.9%）。对于一般住院患者（不包括仅重症监护的研究），COVID-19 的死亡率为 11.5%（95%CI 7.7%至 16.9%，I²=96.7%）。在重症疾病研究（n=7）中，我们发现死亡率为 40.5%（95%CI 31.2%至 50.6%，I²=91.8%）。
一般住院患者和重症监护病例中 COVID-19 死亡率较高，应指导大流行期间资源配置和经济负担的计算。
