重楼属生物碱的化学。

The chemistry of Daphniphyllum alkaloids.

机构信息

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai, China.

出版信息

Alkaloids Chem Biol. 2021;85:113-176. doi: 10.1016/bs.alkal.2021.01.001.

DOI:10.1016/bs.alkal.2021.01.001

PMID:33663752

Abstract

The triterpenoids Daphniphyllum alkaloids share the unique fused hexacyclic ring framework are isolated from the genus Daphniphyllum. These natural products possess comprehensive biological activities and exhibit excellent potential medicinal appliment. This review covers the reported isolation studies and biological activities of Daphniphyllum alkaloids spanning the period from 1966 to the beginning of 2020, In the meantime, the total synthesis of Daphniphyllum alkaloids will be emphatically summarized for supplement over this review series.

摘要

从梫木属植物中分离得到的三萜生物碱类化合物具有独特的稠合六元环骨架。这些天然产物具有广泛的生物活性，显示出良好的药用应用潜力。本综述涵盖了 1966 年至 2020 年初报道的梫木属生物碱的分离研究和生物活性，同时，还将重点总结梫木属生物碱的全合成，以补充本综述系列。