Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming, 650091, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Phytochemistry. 2024 Jul;223:114106. doi: 10.1016/j.phytochem.2024.114106. Epub 2024 Apr 23.
Daphmacrimines A-K (1-11) were isolated from the leaves and stems of Daphniphyllum macropodum Miq. Their structures and stereochemistries were determined by extensive techniques, including HRESIMS, NMR, ECD, IR, and single-crystal X-ray crystallography. Daphmacrimines A-D (1-4) are unprecedented Daphniphyllum alkaloids with a 2-oxazolidinone ring. Daphmacrimine I (9) contains a nitrile group, which is relatively rare in naturally occurring alkaloids. The abilities of daphmacrimines A-D and daphmacrimines G-K to enhance lysosomal biogenesis were evaluated through LysoTracker Red staining. Daphmacrimine K (11) can induce lysosomal biogenesis and promote autophagic flux.
达佛烷型生物碱 1-11 从粗梗水麻叶的叶和茎中分离得到。其结构和立体化学通过包括高分辨质谱、核磁共振、ECD、IR 和单晶 X 射线衍射在内的广泛技术确定。达佛烷型生物碱 A-D（1-4）是具有 2-噁唑烷酮环的前所未有的粗梗水麻叶生物碱。达佛烷型生物碱 I（9）含有一个腈基，这在天然存在的生物碱中相对较少见。通过 LysoTracker Red 染色评估了达佛烷型生物碱 A-D 和 G-K 增强溶酶体生物发生的能力。达佛烷型生物碱 K（11）可以诱导溶酶体生物发生并促进自噬流。
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