Zhang Jun, Tecson Kristen M, McCullough Peter A
Baylor Heart and Vascular Institute, Baylor University Medical Center, Dallas, Texas.
Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
Proc (Bayl Univ Med Cent). 2021 Jan 26;34(2):262-268. doi: 10.1080/08998280.2021.1874231.
Endothelial cell (EC) dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy, and the angiotensin-converting enzyme 2 (ACE2) receptor plays a role in EC dysfunction in COVID-19. To expand the understanding of the role of the ACE2 receptor relative to EC dysfunction, this review addresses (1) tissue distribution of the ACE2 protein and its mRNA expression in humans, (2) susceptibility of the capillary ECs to SARS-CoV-2 infection, and (3) the role of EC dysfunction relevant to ACE2 and nuclear factor-κB in COVID-19.
内皮细胞（EC）功能障碍导致与COVID-19相关的血管炎症和凝血病，而血管紧张素转换酶2（ACE2）受体在COVID-19的EC功能障碍中起作用。为了加深对ACE2受体相对于EC功能障碍作用的理解，本综述探讨了：（1）ACE2蛋白在人体中的组织分布及其mRNA表达；（2）毛细血管ECs对SARS-CoV-2感染的易感性；（3）与ACE2和核因子-κB相关的EC功能障碍在COVID-19中的作用。
