相互易位t(2;5)的人类精子染色体研究
Human sperm chromosome studies in a reciprocal translocation t(2;5).
作者信息
Templado C, Navarro J, Benet J, Genescà A, Pérez M M, Egozcue J
机构信息
Instituto de Biología Fundamental V. Villar Palasí, Bellaterra, Barcelona, Spain.
出版信息
Hum Genet. 1988 May;79(1):24-8. doi: 10.1007/BF00291704.
Sperm chromosome complements have been studied in a man heterozygous for a reciprocal translocation t(2;5)(p11;q15). Human sperm chromosomes were obtained after fertilization of zona-free hamster eggs. A total of 75 human sperm metaphases were analysed. On the complements studied, 59 (78.6%) resulted from a 2:2 segregation and 16 (21.3%) from a 3:1 segregation, 4:0 segregation was not observed. Our results indicate that at least 36% of sperm complements were unbalanced with respect to the translocation. The frequency of other chromosome anomalies unrelated to the translocation was 16%.
对一名携带相互易位t(2;5)(p11;q15)的杂合男性的精子染色体组成进行了研究。通过对无透明带仓鼠卵进行受精后获得人类精子染色体。共分析了75个人类精子中期相。在所研究的染色体组成中，59个（78.6%）来自2:2分离，16个（21.3%）来自3:1分离，未观察到4:0分离。我们的结果表明，至少36%的精子染色体组成在易位方面是不平衡的。与易位无关的其他染色体异常频率为16%。
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