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tRNA衍生片段-3017A通过抑制NELL2促进人胃癌转移。

The tRNA-Derived Fragment-3017A Promotes Metastasis by Inhibiting NELL2 in Human Gastric Cancer.

作者信息

Tong Linhao, Zhang Weixu, Qu Bicheng, Zhang Fei, Wu Zhonghua, Shi Jinxin, Chen Xiaowan, Song Yongxi, Wang Zhenning

机构信息

Department of Surgical Oncology and General Surgery, Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, The First Affiliated Hospital of China Medical University, Shenyang, China.

出版信息

Front Oncol. 2021 Feb 16;10:570916. doi: 10.3389/fonc.2020.570916. eCollection 2020.

DOI:10.3389/fonc.2020.570916
PMID:33665159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7921707/
Abstract

tRNA-derived fragments (tRFs) are a new classification of small non-coding RNAs (sncRNAs) derived from the specific cleavage of precursors and mature tRNAs. Accumulating recent evidence has shown that tRFs are frequently abnormal in several cancers. Nevertheless, the role of tRFs in gastric cancer and its mechanism remain unclear. In this study, we found abnormal expression of tRF-3017A (derived from tRNA-Val-TAC) in gastric cancer tissues and cell lines and confirmed its effect on promoting the invasion and migration of gastric cancer cells through functional experiments . Analysis of clinicopathologic data showed patients with higher tRF-3017A were associated with significantly higher lymph node metastasis. Mechanistic investigation implies that tRF-3017A regulates the tumor suppressor gene NELL2 through forming the RNA-induced silencing complex (RISC) with Argonaute (AGO) proteins. In this study, we found that higher tRF-3017A were associated with significantly higher lymph node metastasis in gastric cancer patients and the tRF-3017A may play a role in promoting the migration and invasion of gastric cancer cells by silencing tumor suppressor NELL2.

摘要

转运RNA衍生片段（tRFs）是一类新的小非编码RNA（sncRNAs），由前体和成熟转运RNA的特异性切割产生。最近越来越多的证据表明，tRFs在几种癌症中经常出现异常。然而，tRFs在胃癌中的作用及其机制仍不清楚。在本研究中，我们发现tRF-3017A（源自tRNA-Val-TAC）在胃癌组织和细胞系中表达异常，并通过功能实验证实了其对促进胃癌细胞侵袭和迁移的作用。临床病理数据分析显示，tRF-3017A水平较高的患者淋巴结转移明显更高。机制研究表明，tRF-3017A通过与AGO蛋白形成RNA诱导沉默复合体（RISC）来调控肿瘤抑制基因NELL2。在本研究中，我们发现tRF-3017A水平较高与胃癌患者的淋巴结转移明显更高有关，并且tRF-3017A可能通过沉默肿瘤抑制因子NELL2在促进胃癌细胞迁移和侵袭中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/7921707/5b0a294cbc64/fonc-10-570916-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/7921707/5b0a294cbc64/fonc-10-570916-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/7921707/a95fbd625b06/fonc-10-570916-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a355/7921707/5b0a294cbc64/fonc-10-570916-g007.jpg

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