Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, United States.
Curr Opin Biotechnol. 2019 Aug;58:202-210. doi: 10.1016/j.copbio.2019.05.014. Epub 2019 Jul 16.
We herein provide a brief review of the trajectory that the field of short RNA research followed in the last 25 years. We place emphasis on the unexpected discoveries and the ramifications of these discoveries for the field, as well as offer some thoughts about what the next 25 years may bring. Arguably, the uncovered dependence of different types of short RNAs on individual attributes such as a person's sex, population origin, race, and on tissue type, tissue state, and disease was most unexpected. This dependence has important ramifications in that it will provide a boost to our understanding of the molecular mechanisms of health disparities as well as pave the way for novel approaches to designing improved and personalized diagnostics and therapeutics.
我们在此简要回顾了过去 25 年短 RNA 研究领域所经历的历程。我们重点介绍了一些意外的发现及其对该领域的影响，并对未来 25 年可能带来的情况进行了一些思考。可以说，不同类型的短 RNA 对个体属性（如性别、人口来源、种族）以及组织类型、组织状态和疾病的依赖，是最令人意外的。这种依赖性具有重要的意义，因为它将有助于我们理解健康差异的分子机制，并为设计更好的个性化诊断和治疗方法铺平道路。
