Yin Guangli, Liao Shengen, Gong Dexing, Qiu Hongxia
Department of Geriatric, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, 210029, China.
Environ Pollut. 2021 May 15;277:116816. doi: 10.1016/j.envpol.2021.116816. Epub 2021 Feb 25.
The frequency and duration of exposure to acrylamide (AA) from the environment and diet are associated with a range of adverse health effects. However, whether long-term AA exposure is related to diabetes mellitus (DM) remains unknown. Data from 3577 adults in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 and 2013-2016 aged ≥ 20 years was analysed. The main analyses applied multivariate logistic regression and restricted cubic spline models to investigate the associations between DM and AA haemoglobin biomarkers, including haemoglobin adducts of acrylamide and glycidamide (HbAA and HbGA), the sum of HbAA and HbGA (HbAA + HbGA), and the ratio of HbGA to HbAA (HbGA/HbAA) levels. After multivariable adjustment, the odds ratios (95% confidence intervals) for DM comparing the highest with the lowest AA haemoglobin biomarker quartiles were 0.71 (0.55, 0.93), 0.92 (0.71, 1.18), 0.80 (0.62, 1.03) and 1.95 (1.51, 2.51) for HbAA, HbGA, HbAA + HbGA and HbGA/HbAA, respectively. The restricted cubic spline model demonstrated that HbAA was linearly and inversely associated with risk of DM (P for trend = 0.013), while HbGA/HbAA was nonlinearly and positively associated with the prevalence of DM (P for trend <0.001). These results support for epidemiological evidence that the HbAA and HbGA/HbAA are significantly associated with DM. Further studies are warranted to infer the causal role of AA exposure in the prevalence of DM.
来自环境和饮食中丙烯酰胺（AA）的暴露频率和持续时间与一系列不良健康影响相关。然而，长期接触AA是否与糖尿病（DM）有关仍不清楚。分析了2005 - 2006年和2013 - 2016年美国国家健康与营养检查调查（NHANES）中3577名年龄≥20岁成年人的数据。主要分析应用多变量逻辑回归和受限立方样条模型来研究DM与AA血红蛋白生物标志物之间的关联，包括丙烯酰胺和环氧丙酰胺的血红蛋白加合物（HbAA和HbGA）、HbAA与HbGA之和（HbAA + HbGA）以及HbGA与HbAA的比值（HbGA/HbAA）水平。多变量调整后，将DM最高与最低AA血红蛋白生物标志物四分位数进行比较的比值比（95%置信区间），HbAA、HbGA、HbAA + HbGA和HbGA/HbAA分别为0.71（0.55，0.93）、0.92（0.71，1.18）、0.80（0.62，1.03）和1.95（1.51，2.51）。受限立方样条模型表明，HbAA与DM风险呈线性负相关（趋势P = 0.013），而HbGA/HbAA与DM患病率呈非线性正相关（趋势P <0.001）。这些结果支持了HbAA和HbGA/HbAA与DM显著相关的流行病学证据。有必要进行进一步研究以推断AA暴露在DM患病率中的因果作用。
