Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Food Safety and Hygiene, School of Health, Fasa University of Medical Sciences, Fasa, Iran.
Sci Rep. 2023 May 22;13(1):8235. doi: 10.1038/s41598-023-35493-x.
This study aimed at investigating the association of acrylamide consumption with the incidence of type 2 diabetes (T2D) in adults. The 6022 subjects of the Tehran lipid and glucose study participants were selected. The acrylamide content of food items were summed and computed cumulatively across follow up surveys. Multivariable Cox proportional hazard regression analyses were performed to estimate the hazards ratio (HR) and 95% confidence interval (CI) of incident T2D. This study was done on men and women, respectively aged 41.5 ± 14.1 and 39.2 ± 13.0 years. The mean ± SD of dietary acrylamide intake was 57.0 ± 46.8 µg/day. Acrylamide intake was not associated with the incidence of T2D after adjusting for confounding variables. In women, a higher acrylamide intake was positively associated with T2D [HR (CI) for Q4: 1.13 (1.01-1.27), P trend: 0.03] after adjusting for confounding factors. Our results demonstrated that dietary intake of acrylamide was associated with an increased risk of T2D in women.
本研究旨在探讨丙烯酰胺摄入与成年人 2 型糖尿病（T2D）发病率之间的关系。从德黑兰血脂和血糖研究参与者中选择了 6022 名受试者。对食物中丙烯酰胺含量进行了累加，并在随访调查中进行了累积计算。采用多变量 Cox 比例风险回归分析来估计 T2D 发病率的风险比（HR）和 95%置信区间（CI）。本研究分别对男性和女性进行了研究，他们的年龄分别为 41.5±14.1 岁和 39.2±13.0 岁。膳食丙烯酰胺摄入量的平均值±标准差为 57.0±46.8μg/天。调整混杂因素后，丙烯酰胺摄入与 T2D 发病率无关。在女性中，在调整混杂因素后，较高的丙烯酰胺摄入量与 T2D 呈正相关[Q4 的 HR（CI）：1.13（1.01-1.27），P 趋势：0.03]。我们的研究结果表明，膳食丙烯酰胺摄入与女性 T2D 风险增加有关。
