Department of Science and Innovation Technology (DISIT), Università del Piemonte Orientale-via T. Michel 11, 15121 Alessandria, Italy.
Innovative Research Laboratory for Wound Healing, Health Sciences Department, Università del Piemonte Orientale, via Solaroli 17, 28100 Novara, Italy.
Cells. 2021 Feb 25;10(3):494. doi: 10.3390/cells10030494.
The neutrophils extracellular traps (NETs) are a meshwork of chromatin, histonic and non-histonic proteins, and microbicidal agents spread outside the cell by a series of nuclear and cytoplasmic events, collectively called NETosis. NETosis, initially only considered a defensive/apoptotic mechanism, is now considered an extreme defensive solution, which in particular situations induces strong negative effects on tissue physiology, causing or exacerbating pathologies as recently shown in NETs-mediated organ damage in COVID-19 patients. The positive effects of NETs on wound healing have been linked to their antimicrobial activity, while the negative effects appear to be more common in a plethora of pathological conditions (such as diabetes) and linked to a NETosis upregulation. Recent evidence suggests there are other positive physiological NETs effects on wound healing that are worthy of a broader research effort.
中性粒细胞细胞外陷阱（NETs）是一种染色质、组蛋白和非组蛋白以及杀菌剂的网状物，通过一系列核和细胞质事件扩散到细胞外，这些事件统称为 NETosis。NETosis 最初仅被认为是一种防御/凋亡机制，现在被认为是一种极端的防御解决方案，特别是在某些情况下，它会对组织生理学产生强烈的负面影响，导致或加剧疾病，如最近在 COVID-19 患者的 NETs 介导的器官损伤中所显示的那样。NETs 对伤口愈合的积极影响与其抗菌活性有关，而在许多病理情况下（如糖尿病），其负面影响似乎更为常见，并且与 NETosis 的上调有关。最近的证据表明，伤口愈合中还有其他积极的生理 NETs 作用值得更广泛的研究。
