Lall Namrita, Chrysargyris Antonios, Lambrechts Isa, Fibrich Bianca, Blom Van Staden Analike, Twilley Danielle, de Canha Marco Nuno, Oosthuizen Carel Basson, Bodiba Dikonketso, Tzortzakis Nikolaos
Department of Plant and Soil Sciences, University of Pretoria, Pretoria 0002, South Africa.
School of Natural Resources, University of Missouri, Columbia, MO 65211, USA.
Antioxidants (Basel). 2019 Oct 30;8(11):521. doi: 10.3390/antiox8110521.
L. subsp. is an endemic species of the Eastern Mediterranean region with several uses in traditional medicine. The present study aims to explore the unknown properties of investigating the nutritional content as well as the antioxidant, anticancer, antituberculosis, antiwrinkle, anti-acne, hyper/hypo-pigmentation and antibacterial activities. Mineral content, nutritional value, the composition and antioxidant properties of the essential oil, the antityrosinase, the antibacterial activity and anti-elastase potential of the extract, were evaluated. The antiproliferative activity of against cervical cancer (HeLa), human melanoma (UCT-Mel-1), human hepatocellular carcinoma (HepG2) and human epidermoid carcinoma (A431) was investigated. Cytotoxic effects on normal human keratinocyte (HaCat) and kidney epithelial (Vero) cell lines were also determined. exhibited high nutritional value of proteins and minerals (K, P, Mg, Fe, Zn, Cu). The most abundant components of the essential oil were found to be α-pinene, β-phelladrene, valeranone, β-pinene and sabinene. The ethanolic extract of displayed moderate antioxidant potential and antibacterial activity against Noteworthy elastase and moderate anticancer potential against the human liver cancer cell line (HepG2) was observed with IC values of 57.18 ± 3.22 μg/mL and 64.27 ± 2.04 μg/mL respectively. The noteworthy activity of could be due to the presence of flavonoids and phenols in the leaves, having high nutritional value. could potentially be useful to reduce the appearance of wrinkles and for the treatment of liver cancer. The moderate antibacterial, antioxidant and elastase activity of the plant can be linked to the traditional use of for the treatment of wounds and inflammation.
L.亚种是东地中海地区的特有物种,在传统医学中有多种用途。本研究旨在通过调查其营养成分以及抗氧化、抗癌、抗结核、抗皱、抗痤疮、色素沉着过度/不足和抗菌活性来探索其未知特性。评估了矿物质含量、营养价值、精油的组成和抗氧化特性、提取物的抗酪氨酸酶、抗菌活性和抗弹性蛋白酶潜力。研究了其对宫颈癌(HeLa)、人黑色素瘤(UCT-Mel-1)、人肝细胞癌(HepG2)和人表皮样癌(A431)的抗增殖活性。还测定了对正常人角质形成细胞(HaCat)和肾上皮(Vero)细胞系的细胞毒性作用。其表现出蛋白质和矿物质(钾、磷、镁、铁、锌、铜)的高营养价值。精油中最丰富的成分是α-蒎烯、β-水芹烯、缬草酮、β-蒎烯和桧烯。其乙醇提取物表现出中等抗氧化潜力和对……的抗菌活性。观察到其对人肝癌细胞系(HepG2)具有显著的弹性蛋白酶活性和中等抗癌潜力,IC值分别为57.18±3.22μg/mL和64.27±2.04μg/mL。其显著的……活性可能归因于叶片中存在黄酮类化合物和酚类物质,具有高营养价值。它可能有助于减少皱纹的出现并用于治疗肝癌。该植物的中等抗菌、抗氧化和弹性蛋白酶活性可与传统上用于治疗伤口和炎症相关联。