• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

超声辅助提取红花籽油中美白抗皱物质的研究

Development of Ultrasound-Assisted Extraction to Produce Skin-Whitening and Anti-Wrinkle Substances from Safflower Seed.

机构信息

Department of Food Science, Sun Moon University, Natural Science 118, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si 336-708, Korea.

FlexPro Biotechnology, Natural Science 128, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si 336-708, Korea.

出版信息

Molecules. 2022 Feb 15;27(4):1296. doi: 10.3390/molecules27041296.

DOI:10.3390/molecules27041296
PMID:35209083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8876410/
Abstract

In this study, ultrasound-assisted extraction (UAE) was applied to extract bioactive substances with skin-whitening, anti-wrinkle, and antioxidant effects from safflower seeds, and the extraction conditions were optimized by a central composite design. The independent variables, including extraction time (5.055.0 min), extraction temperature (26.094.0 °C), and ethanol concentration (0.0~100%), were optimized to increase tyrosinase activity inhibitory (TAI), collagenase activity inhibitory (CAI), and radical scavenging activity (RSA), which are indicators of skin-whitening, anti-wrinkle, and antioxidant effects. An extraction time of 26.4 min, extraction temperature of 52.1 °C, and ethanol concentration of 50.7% were found to be optimum conditions of UAE, under which TAI, CAI, and RSA were 53.3%, 91.5%, and 27.7%, respectively. The extract produced by UAE was analyzed by LC-MS/MS, and maleic acid and levulinic acid were identified as the main substances. Therefore, UAE is evaluated as an effective process to extract skin-whitening, anti-wrinkle, and antioxidant substances from safflower seeds at lower temperatures and shorter extraction times compared to the conventional extraction methods. Overall, safflower seeds extract can be used as a material for value-added cosmetics, including maleic acid and levulinic acid, which have bioactive functions.

摘要

在这项研究中，超声辅助提取（UAE）被应用于从红花种子中提取具有美白、抗皱和抗氧化作用的生物活性物质，并通过中心复合设计优化了提取条件。独立变量包括提取时间（5.055.0 分钟）、提取温度（26.094.0°C）和乙醇浓度（0.0~100%），以提高酪氨酸酶活性抑制率（TAI）、胶原酶活性抑制率（CAI）和自由基清除活性（RSA），这是美白、抗皱和抗氧化作用的指标。发现提取时间为 26.4 分钟、提取温度为 52.1°C、乙醇浓度为 50.7%是 UAE 的最佳条件，在此条件下 TAI、CAI 和 RSA 分别为 53.3%、91.5%和 27.7%。通过 LC-MS/MS 对 UAE 产生的提取物进行分析，鉴定出马来酸和乙酰丙酸是主要物质。因此，与传统提取方法相比，UAE 被评估为一种在较低温度和较短提取时间内从红花种子中提取美白、抗皱和抗氧化物质的有效工艺。总的来说，红花籽油提取物可以作为具有生物活性功能的增值化妆品的原料，包括马来酸和乙酰丙酸。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/c9c9bbd2df6c/molecules-27-01296-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/1f2850679405/molecules-27-01296-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/d54c9f5dac08/molecules-27-01296-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/fcb1589ace6e/molecules-27-01296-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/c90c1df81567/molecules-27-01296-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/9ab21865f6c6/molecules-27-01296-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/c9c9bbd2df6c/molecules-27-01296-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/1f2850679405/molecules-27-01296-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/d54c9f5dac08/molecules-27-01296-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/fcb1589ace6e/molecules-27-01296-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/c90c1df81567/molecules-27-01296-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/9ab21865f6c6/molecules-27-01296-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3830/8876410/c9c9bbd2df6c/molecules-27-01296-g006.jpg

相似文献

1
Development of Ultrasound-Assisted Extraction to Produce Skin-Whitening and Anti-Wrinkle Substances from Safflower Seed.超声辅助提取红花籽油中美白抗皱物质的研究
Molecules. 2022 Feb 15;27(4):1296. doi: 10.3390/molecules27041296.
2
Skin-Whitening and Anti-Wrinkle Effects of Bioactive Compounds Isolated from Peanut Shell Using Ultrasound-Assisted Extraction.超声辅助提取花生壳中生物活性化合物的美白抗皱作用。
Molecules. 2021 Feb 25;26(5):1231. doi: 10.3390/molecules26051231.
3
Effects of Extract on Skin Whitening and Anti-Wrinkling through Inhibition of and .提取物通过抑制和对皮肤美白和抗皱的影响。
Molecules. 2021 Dec 5;26(23):7381. doi: 10.3390/molecules26237381.
4
Ultrasound-assisted extraction of bioactive compounds from longan seeds powder: Kinetic modelling and process optimization.超声辅助提取龙眼籽粉中生物活性化合物：动力学建模与过程优化。
Ultrason Sonochem. 2024 Aug;108:106949. doi: 10.1016/j.ultsonch.2024.106949. Epub 2024 Jun 21.
5
Simultaneous Optimization of the Ultrasonic Extraction Method and Determination of the Antioxidant Activities of Hydroxysafflor Yellow A and Anhydrosafflor Yellow B from Safflower Using a Response Surface Methodology.红花中羟基红花黄色素 A 和脱水红花黄色素 B 的超声提取方法的同时优化及抗氧化活性测定的响应面法。
Molecules. 2020 Mar 9;25(5):1226. doi: 10.3390/molecules25051226.
6
Effective extraction with deep eutectic solvents and enrichment by macroporous adsorption resin of flavonoids from Carthamus tinctorius L.采用深共晶溶剂有效提取并经大孔吸附树脂富集红花中黄酮类化合物
J Pharm Biomed Anal. 2019 Nov 30;176:112804. doi: 10.1016/j.jpba.2019.112804. Epub 2019 Aug 5.
7
Greener extraction process and enhanced in vivo bioavailability of bioactive components from Carthamus tinctorius L. by natural deep eutectic solvents.天然深共晶溶剂对红花中生物活性成分的绿色提取工艺及体内生物利用度的增强作用。
Food Chem. 2021 Jun 30;348:129090. doi: 10.1016/j.foodchem.2021.129090. Epub 2021 Jan 18.
8
Effects of extracts and isolated compounds from safflower on some index of promoting blood circulation and regulating menstruation.红花提取物及分离化合物对某些活血化瘀及调经指标的影响。
J Ethnopharmacol. 2016 Sep 15;191:264-272. doi: 10.1016/j.jep.2016.06.009. Epub 2016 Jun 7.
9
Optimization of ultrasound-assisted extraction of phenolic compounds, antioxidants, and anthocyanins from grape (Vitis vinifera) seeds.超声辅助从葡萄（酿酒葡萄）籽中提取酚类化合物、抗氧化剂和花青素的工艺优化
J Agric Food Chem. 2009 Jun 10;57(11):4988-94. doi: 10.1021/jf9001439.
10
Optimization of Ultrasound-Assisted Extraction of Antioxidants from the Mung Bean Coat.绿豆皮中抗氧化剂的超声辅助提取工艺优化
Molecules. 2017 Apr 15;22(4):638. doi: 10.3390/molecules22040638.

引用本文的文献

1
Unraveling TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Safflower: A Blueprint for Stress Resilience and Metabolic Regulation.解析红花中的TEOSINTE BRANCHED1/ CYCLOIDEA/ PROLIFERATING CELL FACTOR转录因子：应激恢复力和代谢调控蓝图
Molecules. 2025 Jan 10;30(2):254. doi: 10.3390/molecules30020254.
2
Design of Experiments for Optimizing Ultrasound-Assisted Extraction of Bioactive Compounds from Plant-Based Sources.超声辅助植物源生物活性化合物提取的实验设计。
Molecules. 2023 Nov 24;28(23):7752. doi: 10.3390/molecules28237752.
3
Plant Extracts as Skin Care and Therapeutic Agents.

本文引用的文献

1
Effects of Extract on Skin Whitening and Anti-Wrinkling through Inhibition of and .提取物通过抑制和对皮肤美白和抗皱的影响。
Molecules. 2021 Dec 5;26(23):7381. doi: 10.3390/molecules26237381.
2
Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure.靶向杂化纳米载体作为增强皮肤结构的系统。
Molecules. 2021 Feb 18;26(4):1063. doi: 10.3390/molecules26041063.
3
Unravelling property of polysaccharides from Sargassum sp. as an anti-wrinkle and skin whitening property.揭示马尾藻多糖的特性，作为一种抗皱和皮肤美白的特性。
植物提取物在皮肤护理和治疗中的应用。
Int J Mol Sci. 2023 Oct 22;24(20):15444. doi: 10.3390/ijms242015444.
Int J Biol Macromol. 2019 Nov 1;140:216-224. doi: 10.1016/j.ijbiomac.2019.08.027. Epub 2019 Aug 4.
4
Five individual polyphenols as tyrosinase inhibitors: Inhibitory activity, synergistic effect, action mechanism, and molecular docking.五种单体多酚作为酪氨酸酶抑制剂：抑制活性、协同作用、作用机制和分子对接。
Food Chem. 2019 Nov 1;297:124910. doi: 10.1016/j.foodchem.2019.05.184. Epub 2019 May 27.
5
Safflower (Carthamus tinctorius L.) seed attenuates memory impairment induced by scopolamine in mice via regulation of cholinergic dysfunction and oxidative stress.红花（Carthamus tinctorius L.）籽油通过调节胆碱能功能障碍和氧化应激减轻东莨菪碱诱导的小鼠记忆障碍。
Food Funct. 2019 Jun 19;10(6):3650-3659. doi: 10.1039/c9fo00615j.
6
Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils.某些植物油脂的抗炎及皮肤屏障修复作用。
Int J Mol Sci. 2017 Dec 27;19(1):70. doi: 10.3390/ijms19010070.
7
Perceived Age and Life Style. The Specific Contributions of Seven Factors Involved in Health and Beauty.感知年龄与生活方式。健康与美丽所涉及的七个因素的具体贡献。
Maedica (Bucur). 2017 Sep;12(3):191-201.
8
Determination of DPPH Radical Oxidation Caused by Methanolic Extracts of Some Microalgal Species by Linear Regression Analysis of Spectrophotometric Measurements.通过分光光度测量的线性回归分析测定某些微藻物种甲醇提取物引起的DPPH自由基氧化作用。
Sensors (Basel). 2007 Oct 3;7(10):2080-2095. doi: 10.3390/s7102080.
9
4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation.4-正丁基间苯二酚，一种高效的酪氨酸酶抑制剂，用于局部治疗色素沉着过度。
J Eur Acad Dermatol Venereol. 2013 Jan;27 Suppl 1:19-23. doi: 10.1111/jdv.12051.
10
The evaluation of depigmenting efficacy in the skin for the development of new whitening agents in Korea.韩国开发新型美白剂的皮肤脱色功效评估。
Int J Cosmet Sci. 2013 Feb;35(1):9-18. doi: 10.1111/ics.12012. Epub 2012 Nov 8.