Lv Dongyue, Duan Ran, Fan Rong, Mu Hui, Liang Junrong, Xiao Meng, He Zhaokai, Qin Shuai, Yang Jinchuan, Jing Huaiqi, Wang Zhaoguo, Wang Xin
Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, Qingdao 266021, China.
State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Antibiotics (Basel). 2021 Feb 25;10(3):233. doi: 10.3390/antibiotics10030233.
Antibiotic resistance has become a global public health concern. To determine the distribution characteristics of and in China, gene screening was conducted directly from gut specimens sourced from livestock and poultry, poultry environments, human diarrhea patients, and wild animals from 10 regions, between 2010-2020. The positive rate was 5.09% (356/6991) for and 0.41% (29/6991) for , as detected in gut specimens from seven regions, throughout 2010 to 2019, but not detected in 2020. The detection rate of showed significant differences among various sources: livestock and poultry (14.81%) > diarrhea patients (1.43%) > wild animals (0.36%). The detection rate of was also higher in livestock and poultry (0.88%) than in diarrhea patients (0.17%), and this was undetected in wildlife. This is consistent with the relatively high detection rate of multiple genotypes in livestock and poultry. All instances of coexistence of the and genes, as well as coexistence of genotypes within single specimens, and most new subtypes came from livestock, and poultry environments. Our study indicates that the emergence of and genes in China is closely related to the selective pressure of carbapenem and polymyxin. The gene-based strategy is proposed to identify more resistance genes of concern, possibly providing guidance for the prevention and control of antimicrobial resistance dissemination.
抗生素耐药性已成为全球公共卫生问题。为确定中国[具体基因名称1]和[具体基因名称2]的分布特征，于2010 - 2020年期间直接从10个地区的家畜家禽、家禽养殖环境、人类腹泻患者及野生动物的肠道标本中进行基因筛查。在2010年至2019年期间，七个地区的肠道标本中检测到[具体基因名称1]的阳性率为5.09%（356/6991），[具体基因名称2]的阳性率为0.41%（29/6991），但在2020年未检测到。[具体基因名称1]在不同来源中的检出率存在显著差异：家畜家禽（14.81%）>腹泻患者（1.43%）>野生动物（0.36%）。[具体基因名称2]在家畜家禽中的检出率（0.88%）也高于腹泻患者（0.17%），在野生动物中未检出。这与家畜家禽中多种[具体基因名称1]基因型相对较高的检出率一致。[具体基因名称1]和[具体基因名称2]基因共存的所有情况，以及单个标本中[具体基因名称1]基因型的共存情况，且大多数新的[具体基因名称1]亚型均来自家畜和家禽养殖环境。我们的研究表明，中国[具体基因名称1]和[具体基因名称2]基因的出现与碳青霉烯类和多粘菌素的选择压力密切相关。建议采用基于基因的策略来识别更多值得关注的耐药基因，这可能为抗菌药物耐药性传播的预防和控制提供指导。
