血清硒浓度与癌症风险相关。
Serum selenium concentration associated with risk of cancer.
作者信息
Ringstad J, Jacobsen B K, Tretli S, Thomassen Y
机构信息
Institute of Community Medicine, University of Tromsø, Norway.
出版信息
J Clin Pathol. 1988 Apr;41(4):454-7. doi: 10.1136/jcp.41.4.454.
The association between serum selenium concentration and risk of cancer was studied in a nested case control study. Case control pairs came from a population of 9364 people examined in 1979. During the six year follow up, 60 men and women aged between 20-54 at the time of blood sampling, who had been free of malignant disease, developed cancer. The mean serum selenium concentration of 1.56 mumol/l (123.2 micrograms/l) in patients was not significantly different from that in controls (1.63 mumol/l (128.7 micrograms/l]. The difference in mean selenium concentration was largest and most significant for haematological malignancies alone. The difference in selenium concentrations in cases of fatal cancer compared with controls was significant (p less than 0.01). The risk of developing adenocarcinomas does not seem to be influenced by serum selenium concentration.
在一项巢式病例对照研究中，对血清硒浓度与癌症风险之间的关联进行了研究。病例对照对来自1979年接受检查的9364人的人群。在六年的随访期间，60名在采血时年龄在20 - 54岁之间、且无恶性疾病的男性和女性患上了癌症。患者的血清硒平均浓度为1.56微摩尔/升（123.2微克/升），与对照组（1.63微摩尔/升（128.7微克/升））没有显著差异。仅血液系统恶性肿瘤的平均硒浓度差异最大且最显著。与对照组相比，致命癌症患者的硒浓度差异显著（p小于0.01）。腺癌的发病风险似乎不受血清硒浓度的影响。
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