Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia.
Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj 11942, Saudi Arabia.
Cells. 2021 Feb 21;10(2):460. doi: 10.3390/cells10020460.
Sirtuins (SIRTs) are nicotinamide adenine dinucleotide-dependent histone deacetylases that incorporate complex functions in the mechanisms of cell physiology. Mammals have seven distinct members of the SIRT family (SIRT1-7), which play an important role in a well-maintained network of metabolic pathways that control and adapt the cell to the environment, energy availability and cellular stress. Until recently, very few studies investigated the role of SIRTs in modulating viral infection and progeny. Recent studies have demonstrated that SIRT1 and SIRT2 are promising antiviral targets because of their specific connection to numerous metabolic and regulatory processes affected during infection. In the present review, we summarize some of the recent progress in SIRTs biochemistry and their emerging function as antiviral targets. We also discuss the potential of natural polyphenol-based SIRT modulators to control their functional roles in several diseases including viral infections.
沉默调节蛋白（SIRTs）是烟酰胺腺嘌呤二核苷酸依赖性组蛋白去乙酰化酶，在细胞生理学机制中具有复杂的功能。哺乳动物有七种不同的 SIRT 家族成员（SIRT1-7），它们在维持代谢途径的网络中发挥重要作用，这些代谢途径控制并使细胞适应环境、能量供应和细胞应激。直到最近，很少有研究调查 SIRTs 在调节病毒感染和后代方面的作用。最近的研究表明，SIRT1 和 SIRT2 是很有前途的抗病毒靶点，因为它们与感染过程中受影响的许多代谢和调节过程有特定的联系。在本综述中，我们总结了 SIRTs 生化的一些最新进展及其作为抗病毒靶点的新兴功能。我们还讨论了基于天然多酚的 SIRT 调节剂控制其在包括病毒感染在内的几种疾病中的功能作用的潜力。
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