Sansone Pasquale, Giaccari Luca Gregorio, Aurilio Caterina, Coppolino Francesco, Esposito Valentina, Fiore Marco, Paladini Antonella, Passavanti Maria Beatrice, Pota Vincenzo, Pace Maria Caterina
Department of Woman, Child and General and Specialized Surgery, University of Campania Luigi Vanvitelli, 80138 Napoli, Italy.
Cotugno Hospital, Azienda Ospedaliera dei Colli, 80131 Napoli, Italy.
Life (Basel). 2021 Feb 21;11(2):167. doi: 10.3390/life11020167.
Guillain-Barré syndrome (GBS) is the most common cause of flaccid paralysis, with about 100,000 people developing the disorder every year worldwide. Recently, the incidence of GBS has increased during the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) epidemics. We reviewed the literature to give a comprehensive overview of the demographic characteristics, clinical features, diagnostic investigations, and outcome of SARS-CoV-2-related GBS patients. Embase, MEDLINE, Google Scholar, and Cochrane Central Trials Register were systematically searched on 24 September 2020 for studies reporting on GBS secondary to COVID-19. We identified 63 articles; we included 32 studies in our review. A total of 41 GBS cases with a confirmed or probable COVID-19 infection were reported: 26 of them were single case reports and 6 case series. Published studies on SARS-CoV-2-related GBS typically report a classic sensorimotor type of GBS often with a demyelinating electrophysiological subtype. Miller Fisher syndrome was reported in a quarter of the cases. In 78.1% of the cases, the response to immunomodulating therapy is favourable. The disease course is frequently severe and about one-third of the patients with SARS-CoV-2-associated GBS requires mechanical ventilation and Intensive Care Unit (ICU) admission. Rarely the outcome is poor or even fatal (10.8% of the cases). Clinical presentation, course, response to treatment, and outcome are similar in SARS-CoV-2-associated GBS and GBS due to other triggers.
吉兰-巴雷综合征（GBS）是弛缓性麻痹最常见的病因，全球每年约有10万人罹患该病。近期，在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）流行期间，GBS的发病率有所上升。我们回顾了相关文献，以全面概述与SARS-CoV-2相关的GBS患者的人口统计学特征、临床特征、诊断检查及预后情况。2020年9月24日，我们系统检索了Embase、MEDLINE、谷歌学术和考克兰中央试验注册库，以查找关于继发于新型冠状病毒肺炎（COVID-19）的GBS的研究报告。我们共识别出63篇文章，纳入本综述的有32项研究。共报告了41例确诊或疑似感染COVID-19的GBS病例：其中26例为单病例报告，6例为病例系列研究。关于与SARS-CoV-2相关的GBS的已发表研究通常报告的是经典的感觉运动型GBS，其电生理亚型常为脱髓鞘型。四分之一的病例报告了米勒-费希尔综合征。78.1%的病例对免疫调节治疗反应良好。疾病进程通常较为严重，约三分之一的SARS-CoV-2相关GBS患者需要机械通气并入住重症监护病房（ICU）。极少出现预后不良甚至死亡的情况（占病例的10.8%）。与SARS-CoV-2相关的GBS和由其他诱因引起的GBS在临床表现、病程、治疗反应及预后方面相似。
