Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Road, Niao-Sung, Kaohsiung 833, Taiwan.
Biomed Res Int. 2013;2013:974614. doi: 10.1155/2013/974614. Epub 2013 Sep 4.
Electrical impedance is one of the most frequently used parameters for characterizing material properties. The resistive and capacitive characteristics of tissue may be revealed by electrical impedance spectroscopy (EIS) as electrical biopsy. This technique could be used to monitor the sequelae after irradiation. In this study, rat intestinal tissues after irradiation were assessed by EIS system based on commercially available integrated circuits. The EIS results were fitted to a resistor-capacitor circuit model to determine the electrical properties of the tissue. The variations in the electrical characteristics of the tissue were compared to radiation injury score (RIS) by morphological and histological findings. The electrical properties, based on receiver operation curve (ROC) analysis, strongly reflected the histological changes with excellent diagnosis performance. The results of this study suggest that electrical biopsy reflects histological changes after irradiation. This approach may significantly augment the evaluation of tissue after irradiation. It could provide rapid results for decision making in monitoring radiation sequelae prospectively.
电阻抗是用于描述材料特性的最常用参数之一。通过电阻抗谱（EIS）作为电活检，可以揭示组织的电阻和电容特性。该技术可用于监测照射后的后遗症。在这项研究中，通过基于市售集成电路的 EIS 系统评估了照射后的大鼠肠组织。EIS 结果拟合到电阻-电容电路模型以确定组织的电学特性。通过形态学和组织学发现，将组织电特性的变化与辐射损伤评分（RIS）进行比较。基于接收者操作曲线（ROC）分析的电特性强烈反映了组织学变化，具有出色的诊断性能。本研究结果表明，电活检反映了照射后的组织学变化。这种方法可能会极大地增强对照射后组织的评估。它可以为前瞻性监测辐射后遗症的决策提供快速结果。
