Department of Pharmaceutical Sciences, School of Natural Sciences, Universidad Icesi, Cali 760031, Colombia.
Escuela de Química, Universidad Industrial de Santander, Bucaramanga 680003, Colombia.
Molecules. 2021 Feb 18;26(4):1064. doi: 10.3390/molecules26041064.
Promising research over the past decades has shown that some types of pentacyclic triterpenes (PTs) are associated with the prevention of type 2 diabetes (T2D), especially those found in foods. The most abundant edible sources of PTs are those belonging to the ursane and oleanane scaffold. The principal finding is that contains abundant oleanane and ursane PT types with similar oxygenation patterns to those found in food matrices. We studied the compositional profile of a rich PT fraction (DE16-R) and carried out a viability test over different cell lines. The biosynthetic pathway connected to the isolated PTs in offers a specific medicinal benefit related to the modulation of T2D. This current study suggests that this plant can assemble isobaric, positional isomers or epimeric PT. Ursane or oleanane scaffolds with the same oxygenation pattern are always shared by the PTs in , as demonstrated by its biosynthetic pathway. Local communities have long used this plant in traditional medicine, and humans have consumed ursane and oleanane PTs in fruits since ancient times, two key points we believe useful in considering the medicinal benefits of and explaining how a group of molecules sharing a closely related scaffold can express effectiveness.
在过去几十年的研究中,有一些有前景的研究表明,某些类型的五环三萜(PTs)与预防 2 型糖尿病(T2D)有关,特别是在食物中发现的那些。PTs 的最丰富的可食用来源是那些属于熊烷和齐墩烷支架的。主要发现是 含有丰富的齐墩烷和熊烷 PT 类型,其氧合模式与食物基质中发现的相似。我们研究了丰富的 PT 部分(DE16-R)的组成概况,并对不同的细胞系进行了生存能力测试。与 中分离的 PTs 相关的生物合成途径提供了与调节 T2D 相关的特定药用益处。本研究表明,该植物可以组装等质量、位置异构或差向异构体的 PT。齐墩烷或熊烷支架具有相同的氧合模式,总是由 的 PT 共享,这正如其生物合成途径所证明的那样。当地社区长期以来一直在传统医学中使用这种植物,人类自古以来就在水果中摄入齐墩烷和熊烷 PT,我们认为这两点在考虑 的药用益处以及解释一组共享密切相关支架的分子如何表达有效性方面非常有用。