Leeton J, Freemann L, King C, Brady T, Cameron I, Harman J
Monash-Epworth in Vitro Fertilization Program, Epworth Hospital, Richmond, Victoria, Australia.
J In Vitro Fert Embryo Transf. 1988 Feb;5(1):22-4. doi: 10.1007/BF01138865.
A fertile woman suffering from mild dystrophia myotonica had undergone sterilization because of the 50% genetic risk of this disease developing in her offspring. In her second treatment cycle on the donor oocyte program, four anonymously donated oocytes were inseminated with frozen-thawed sperm of her husband. Three embryos were obtained and two surviving embryos were deep-frozen at the eight-cell stage and kept in storage for 9 months. These embryos were successfully thawed and transferred to the recipient 97 hr after the onset of her luteinizing hormone surge. A normal singleton pregnancy developed and a healthy male infant was delivered by cesarean section at 36 weeks of gestation.
一名患有轻度强直性肌营养不良症的育龄妇女因担心其后代有50%的遗传患病风险而接受了绝育手术。在她接受供体卵母细胞计划的第二个治疗周期中，四个匿名捐赠的卵母细胞与她丈夫的冻融精子进行了授精。获得了三个胚胎，两个存活的胚胎在八细胞阶段进行了深度冷冻，并保存了9个月。这些胚胎在黄体生成素激增开始97小时后成功解冻并移植到受体体内。随后成功发育为单胎正常妊娠，并在妊娠36周时通过剖宫产分娩出一名健康男婴。
